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Functional Characterization Of The Saccharomyces Cerevisiae Splicing Factor, Prp17 In pre-mRNA Splicing And Cell Cycle Progression: An Analysis Through Global Expression Profiling, Protein Interactions And Spliceosomal Associations
(2007-08-30)
The presence of introns in all the eukaryotic genomes identified so far underscores the fundamental and ubiquitous role of pre-mRNA splicing. The spliceosomal machinery, comprised of five small nuclear RNAs and several ...
Transcriptional Analysis Of The Principal Cell Division Gene ftsZ Of Mycobacterium Tuberculosis And Mycobacterium Smegmatis
(2009-03-04)
The success of Mycobacterium tuberculosis as a pathogen is due to its remarkable
ability to: (i). adapt to and survive inside activated macrophages under nonproliferating condition, (ii). put up drug resistance ...
Role Of Matrix Protein Of Rinderpest Virus In Viral Morphogenesis
(2008-10-20)
Rinderpest virus is an enveloped Nonsegmented Negative Stranded RNA Virus (NNSV) belonging to the genus Morbillivirus in the Family Paramyxoviridae and the causative organism for “cattle plague”. The virion has a transport ...
Breast Cancer Susceptibility Gene 1 (BRCA1) And Breast Cancer
(2009-04-15)
Breast Cancer susceptibility gene 1 (BRCA1) & Breast Cancer
Breast cancer is one of the most common malignancies affecting women worldwide. About 5-10% of all cases are estimated to be familial. Mutations in the BRCA1 ...
Molecular Characterisation Of The ATP Binding Cassette (ABC) Transporter Type FtsE And FtsX Proteins Of Mycobacterium Tuberculosis
(2008-09-30)
Mycobacterium tuberculosis, the principal causative agent of tuberculosis (TB) in
humans, is considered to be a successful pathogen owing to the elicitation of multidrug resistance, ability to survive inside macrophage ...
Mechanism Of Ribosome Recycling In Eubacteria, And The Impact Of rRNA Methylations On Ribosome Recycling And Fidelity Of Initiation In Esherichia coli
(2009-12-09)
The studies reported in this thesis address, firstly, aspects of ribosome recycling in eubacteria, and secondly, a preliminary characterization of an EFG-like locus from Mycobacterium smegmatis. A hitherto unsuspected role ...
Transcriptional Regulation And The Role Of Galactose Metabolism In The Virulence Of Candida Albicans
(2009-06-24)
Candida albicans, a commensal of gastrointestinal and uro-vaginal tract can cause superficial as well as life threatening disseminated infections under conditions of lowered immunity of the host such as HIV infection, ...
Rinderpest Virus Transcription : Functional Dissection Of Viral RNA Polymerase And Role Of Host Factor Ebp1 In Virus Multiplication
(2009-11-23)
Rinderpest virus (RPV) belongs to the order Mononegavirale which comprises non segmented negative sense RNA viruses including human pathogens such as Measles, Ebola and Marburg virus. RPV is the causative agent of Rinderpest ...
Evaluation Of The Efficacy Of DNA Vaccines For Japanese Encephalitis In A Murine Intracerebral Japanese Encephalitis Virus Challenge Model
(Indian Institute of Science, 2005-12-05)
Japanese encephalitis virus (JEV), a member of the family flaviviridae, is one of the most important pathogens of the developing countries, causing high mortality and morbidity amongst children. The present study is aimed ...
Diaminopropionate Ammonia Lyase : Characterization, Unfolding And Mechanism Of Inhibition By Aminooxy Compounds
(2009-03-13)
Diaminopropionate ammonia lyase (DAPAL) which belongs to the class of PLP enzymes is reported only from prokaryotes. It is involved in the removal of two amino groups from its substrate, diaminopropionate, to form ammonia ...