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Structural Studies on Heat Shock Protein 90 from Dictyostelium Discoideum and Oryza Sativa
(2018-05-09)
Molecular chaperones are proteins that interact with and aid in stabilization and activation of other proteins. Chaperones help proteins attain their three dimensional conformation, without forming a part of the final ...
Protein Engineering and Stabilization of HIV-1 Envelope Glycoprotein
(2018-05-09)
A number of viral diseases such as Hepatitis B, small pox, measles, rubella and polio have effective vaccines to control or eradicate them. HIV-1 is a lentivirus which infects human immune cells and leads to the disease ...
Structural Studies on the Role of Hinge involved in Domain Swapping in Salmonella Typhimurium Stationary Phase Survival Protein (SurE) and Sesbania Mosaic Virus Coat Protein
(2018-05-09)
A unique mechanism of protein oligomerization is domain swapping. It is a feature found in some proteins wherein a dimer or a higher oligomer is formed by the exchange of identical structural segments between protomers. ...
Small Heat Shock Proteins from Oryza Sativa and Salmonella Enterica
(2018-05-09)
Small heat shock proteins (sHSPs) are a ubiquitous family of molecular chaperones that play a vital role in maintaining protein homeostasis in cells. They are the first line of defence against the detrimental effects of ...
Structural and Related Studies on Mycobacterial Lectins
(2018-05-09)
This thesis is concerned with the first ever X-ray crystallographic and complimentary solution studies on mycobacterial lectins. Lectins, described as multivalent carbohydrate binding proteins of non-immune origin, are ...
Molecular Characterization of Bacillus Subtilis Oxidoreductases involved in the Bacilysin Synthesis
(2018-05-11)
The biosynthetic pathway for the production of the dipeptide antibiotic bacilysin has been the subject of intense research over the past three decades. These studies revealed the role of multiple enzymes in the biosynthesis ...
Host-Pathogen Interactions in Hepatitis C Virus Infection : Deciphering the Role of Host Proteins and MicroRNAs
(2018-07-19)
Host-pathogen interactions in Hepatitis C Virus infection: Deciphering the role of host proteins and microRNAs
Hepatitis C virus (HCV) is a positive sense single stranded RNA virus belonging to the Hepacivirus genus of ...
Functional Insights into PRR-Driven SHH Signaling : Implications for Host-Microbial Interactions
(2018-07-26)
Mycobacterium are important human pathogens and their strength lies in establishing acute infections, latent infections as well as co-existing with other dreadful infectious agents like HIV. The success of mycobacterium ...
Enterovirus Non-structural Protein 3A Interactions with Sec12, an upstream Component of the COPII Secretory Pathway and Implications for Viral Replication
(2018-07-20)
Polioviruses, Coxsackieviruses, and Echoviruses belonging to the Picornaviridae family of positive-stranded, non-enveloped viruses, are highly infectious and associated with a range of illnesses in children from minor ...
Mechanism of Recycling of Ribosomes Stalled on mRNAs in Escherichia Coli
(2018-07-28)
Studies reported in this thesis address the question of how pre-termination ribosomal complexes stalled during translation of mRNA are recycled. The process of recycling of the stalled ribosomes involves many translational ...