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Targeting The CD4 Biniding Site In HIV-1 Immunogen Design
(2016-11-15)
Over three decades have passed since the discovery of HIV-1, yet an AIDS vaccine remains elusive. The envelope glycoprotein of HIV-1 gp120, is the most exposed protein on the viral surface and thus serves as an important ...
Understanding Functions for Fission Yeast Pre-mRNA Splicing Factors SpPrp18 and SpSlu7 in Constitutive and Alternative Splicing
(2017-11-29)
Exonic sequences of eukaryotic genes are interspersed with introns which when accurately removed from the primary transcript (pre-mRNA) results in a functional transcript. These splicing reactions are carried out by the ...
Probing Macromolecular Reactions At Reduced Dimensionality : Mapping Of Sequence Specific And Non-Specific Protein-Ligand lnteractions
(2015-09-03)
During the past decade the effects of macromolecular crowding on reaction pathways is gaining in prominence. The stress is to move out of the realms of ideal solution studies and make conceptual modifications that consider ...
Structural and Functional Studies on Pyridoxal 5′-Phosphate Dependent Lyases and Aminotransferases
(2017-11-30)
The thesis describes structural and functional studies of two PLP-dependent enzymes, diaminopropionate (DAP) ammonia lyase (DAPAL) and N-acetylornithine aminotransferase (AcOAT). The main objective of this work was to ...
Mass Spectrometric Deconvolution of Libraries of Natural Peptide Toxins
(2018-03-24)
This thesis deals with the analysis of natural peptide libraries using mass spectrometry. In the course of the study, both ribosomal and non-ribosomal classes of peptides have been investigated. Microheterogeneity, ...
Structural And Evolutionary Studies On Protein-Protein Interactions
(2014-05-27)
The last few decades have witnessed an upsurge in the availability of large-scale data on genomes and genome-scale information. The development of methods to understand the trends and patterns from large scale data promised ...
Structure, Stability and Evolution of Multi-Domain Proteins
(2018-04-11)
Analyses of protein sequences from diverse genomes have revealed the ubiquitous nature of multi-domain proteins. They form up to 70% of proteomes of most eukaryotic organisms. Yet, our understanding of protein structure, ...