Regulation of transcription initiation is the major determining event employed by the cell to control gene expression and subsequent cellular processes. The weak promoters, with low basal transcription activities, are ...

Cells constantly encounter genotoxic stress arising from extrinsic environmental factors or intrinsic metabolic byproducts. In response, cells activate a robust DNA damage response (DDR) network to preserve genomic stability. ...

Role of PARP16 in cardiac remodeling Cardiac remodeling, a complex process involving alterations in myocardial structure and function, is a major contributor to heart failure. While physiological remodeling supports cardiac ...