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A Comparative Study On The Sensitivity Of Cells Of Different Lineages To Plant Ribosome Inactivating Protein - Abrin
(2010-12-08)
Proteins with selective toxicity have been investigated for use in many ways. One class of proteins, ribosome-inactivating proteins (RIPs), is found throughout the plant kingdom as well as in lower organisms like certain ...
Towards The Understanding Of The Structural Biology Of Histone H1
(Indian Institute of Science, 2005-11-23)
In the eukaryotic nucleus, an immense length of DNA is compactly packaged to generate an ordered three-dimensional hierarchical structure called chromatin (van Holde, 1988; Wolffe, A.P, 1998). This organization forms a ...
Mechanism Of mom Gene Transactivation By Transcription Factor C Of Phage MU
(Indian Institute of Science, 2007-04-26)
Regulation of transcription initiation is the major determining event employed by the cell to control gene expression and subsequent cellular processes. The weak promoters, with low basal transcription activities, are ...
Mechanism of Abrin-Induced Apoptosis and Insights into the Neutralizing Activity of mAb D6F10
(2017-11-23)
Abrin is a potent toxin obtained from the seeds of Abrus precatorius. It is a heterodimeric glycoprotein consisting of an A and a B subunit linked together by a disulfide bond. The toxicity of the protein comes from the A ...
Notch1-Induced Survival Signaling And Its Implications In Cancer Therapeutics
(2009-04-15)
Notch receptors and ligands are type I transmembrane proteins that regulate
development and differentiation during cell-cell contact. There are four Notch receptor
homologues and five notch ligands, identified in humans ...
Evolutionary Design Of Active Site Plasticity In R.KpnI For Promiscuity In Metal Ion Utilization And Substrate Recognition
(2013-03-27)
Restriction modification (R-M) systems are important components of the prokaryotic arsenal against invading genomes. R-M systems directly target the foreign DNA and are often considered as primitive immune systems in ...