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Regulation of the Principal Cell Division Protein FtsZ of Escherichia Coli by Antisense RNA and FtsH Protease
(2018-05-10)
The PhD thesis is on the studsy of the influence of the ftsZ antisense RNA and FtsH protease on the synthesis and function of the Escherichia coli cytokinetic protein, FtsZ, which mediates septation during cell division. ...
Characterization of Host Protein Interactions with HCV RNA : Implications in Viral Translation, Replication and Design of Antivirals
(2018-05-09)
HCV genome is a positive sense single-stranded RNA containing a single open reading frame (ORF) flanked by untranslated regions (UTRs), 5’UTR and 3’UTR.Initiation of HCV RNA translation is mediated by internal ribosome ...
Immune Evasion and Survival Strategies of Mycobacterium : Role for Host Signaling Pathway-Mediated Micro RNAs and Epigenetic Regulation
(2018-05-09)
The genus Mycobacterium represents more than 120 species of bacteria including the pathogenic M. tuberculosis, the etiological agent of tuberculosis. The host mounts a robust inflammatory and cell-mediated response to ...
Insights into Occurrence and Divergence of Intrinsic Terminators and Studies on Rho-Dependent Termination in Mycobacterium Tuberculosis
(2018-04-11)
Two mechanisms, intrinsic and factor-dependent, have evolved for accomplishing the termination of transcription in eubacteria. In this thesis, the first chapter is an introduction to the topic that presents what is known ...
Proteomic Approaches to Study Glioma Development, Progression and Therapy
(2018-04-02)
Astrocytoma, the tumor of astrocytic origin, accounts for about 60 % of the primary
brain tumors. As per World Health Organization grading system, astrocytoma is classified as circumscribed astrocytoma (Grade I; pilocytic ...
Role of DNA Methylation in Glioblastoma Development
(2018-04-11)
Glioblastoma (GBM) is the most common and malignant of the glial tumors. These tumors may develop from lower-grade astrocytomas (diffuse astrocytoma; grade II or anaplastic astrocytoma; grade III) through a progressive ...
The Role of Initiation Factor 3 : Insights from E. Coli, Mitochondria and Mycoplasma
(2018-01-07)
The process of translation initiation is the most highly regulated step of protein synthesis. In bacteria, three initiation factors (IF1, IF2 and IF3) play crucial roles during initiation. IF3 acts as an anti-association ...
Role of SIRT6 in Myofibroblast Cell Death
(2018-01-10)
Cardiovascular diseases are one of the leading causes of mortality. A common denominator across most of the cardiovascular diseases like diabetic cardiomyopathy, hypertrophic cardiomyopathy, myocardial infarction and dilated ...
Role of Mammalian RAD51 Paralogs in Genome Maintenance and Tumor Suppression
(2018-01-28)
My research was focused on understanding the importance of mammalian RAD51 paralogs in genome maintenance and suppression of tumorigenesis. The investigation carried out during this study has been addressed toward gaining ...
Unraveling the Intricate Architecture of Human Mitochondrial Presequence Translocase - Insights on its Evolution and Role in Tumourigenesis
(2018-04-23)
The present thesis focuses on the elucidation of human mitochondrial inner membrane presequence-translocation machinery with implications on cancer cell proliferation. Mitochondria are the endosymbiotic organelles in an ...