Browsing Division of Biological Sciences by Title
Now showing items 514-533 of 1022
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Molecular Insights into Lymphoid Malignancy : Role of Transcription Factor BCL11B in T-cell Leukemia Genesis and Biochemical Characterization of DNA Binding Domain of RAG1
(2018-06-29)The lymphoid tissues consist of distinct cell subpopulations of B and T cell lineages and possess complex signaling pathways that are controlled by a myriad of molecular interactions. During the fine-tuned developmental ... -
Molecular Insights into the Structure and Function of Pepper Vein Banding Virus Encoded Proteins and Endocytic Uptake Pathway of Virus-like Particles into Mammalian Cells
Viruses are major pathogenic agents that cause a variety of diseases in all living systems. Since their first isolation in 1892 by Dimitrii Ivanovsky, methods of their diagnosis and control, their life cycles, host - virus ... -
Molecular Mechanisms Underlying Phosphatidylinositol-Specific Phospholipase C Mediated Regulation Of Lipid Metabolism
(2016-03-04)Phosphoinositide-specific phospholipase C (PLC) is involved in Ca2+ mediated signalling events that lead to altered cellular status. PLC activation causes hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) and ... -
Molecular pathways governing maturation and decay of precursor piRNAs in Caenorhabditis elegans
Piwi-interacting RNAs (piRNAs) are an animal-specific class of germline-enriched small non-coding RNAs that play a crucial role in germline development and fertility in diverse organisms. In Caenorhabditis elegans (C. ... -
Molecular Phenotyping of Mutations in Guanylyi Cyclase C Associated with Congenital Diarrhea
(2018-02-28)Guanylyl cyclase C (GC-C) is a member of particulate guanylyl cyclases, discovered primarily as the target of a family of heat stable enterotoxins (ST), produced by enterotoxigenic Escherichia coli (ETEC). ST is acknowledged ... -
A molecular systems approach to unravel mechanisms and targets in antifolate-resistant bacteria and cancers
Antifolates such as trimethoprim (TMP) and methotrexate (MTX) widely used for treating bacterial infections and certain cancers respectively, inhibit dihydrofolate reductase (DHFR) in the folate pathway. However, the use ... -
Moonlighting Functions of the Rv0805 Phosphodiesterase from Mycobacterium Tuberculosis
(2018-04-18)All organisms must sense and respond to their environment in order to survive. The processes that allow a living cell to sense changes in its environment, and respond appropriately are collectively referred to as ‘signal ... -
Multi-faceted modular interactions in proteins
All living systems are composed of plethora of biomolecules. There are various types of biomolecules such as proteins, DNA, RNA, carbohydrates and metabolites. All the reactions in a biological system involve interactions ... -
Multimodal Duetting and Pair Formation in a Paleotropical False Leaf Katydid, Onomarchus uninotatus
The spectacular diversity in the pair-formation strategies among animal groups has attracted the attention of many over the years. The roots of this diversity lie in the diversity of challenges that males and females face ... -
Multiple routes to tackling drug-resistant tuberculosis: Systems modeling to unravel resistance mechanisms, drug combinations, and novel host-based biomarkers
Tuberculosis (TB) has been a major public health problem. The successful treatment of TB requires long-term (6-months) multi-drug chemotherapy, but poor patient compliance and non-adherence lead to the evolution of ... -
Mutational sensitivity of CcdB mutants in their native operonic context
Determining the precise effects of thousands of point mutants on protein structure, stability, and activity is a challenging task. Chapter 1 introduces how next-generation sequencing technologies exploit phenotypic screens ... -
Mxr1p is a Global Regulator of Multiple Metabolic Pathways in the Methylotrophic Yeast Pichia Pastoris
(2018-03-01)The present study is aimed at examining the ability of Pichia pastoris to utilize acetate and amino acids as the sole sources of carbon. We demonstrate that the zinc finger transcription factor Mxr1p, which is a positive ... -
Mycobacterium Leprae RecA Intein : A LAGLIDADG Homing Endonuclease, Displays A Unique Mode Of DNA Binding And Catalysis Compared To A Canonical LAGLIDADG Homing Enzyme
(2010-09-30)Mobile genetic elements are DNA sequences that move around to different positions within one genome or between different genomes. Mobile DNA elements were initially considered as selfish DNA sequences parasitizing the ... -
Mycobacterium Smegmatis RecA And SSB : Structure-Function Relationships, Interaction With Cofactors And Accessory Proteins
(2011-04-06)Homologous genetic recombination, because of its fundamental roles in the maintenance of genome stability and evolution, is an essential cellular function common to all organisms. This process also plays important roles ... -
Mycobacterium tuberculosis RecA intein, a novel LAGLIDADG homing endonuclease, displays dual target specificity in the presence of alternative cofactors
(Indian Institute of Science, 2005-05-10)Mobile inteins and introns are genetic elements capable of self-propagation by “homing” into host genes and occur in entire taxonomy: eubacteria, eukarya, archaea and viruses. The process of “homing” is promoted by an ... -
Network Heterogeneities, Intrinsic Plasticity and Decorrelation in the Dentate Gyrus
A central premise for research in neuroscience is to mechanistically decipher the physiological roles of the brain in effectuating learning and memory. The tripartite framework that is at the core of learning and memory ... -
Neural Correlates and Behavioral Underpinnings of Remote Memories during Systems Consolidation
Remote retrieval of declarative memories has been under investigation for a long time. After acquisition, long-term encoding of memories happens through crosstalk across multiple brain regions. Through systems consolidation, ... -
Neural Mechanisms underlying the planning of sequential saccades
Saccades are rapid eye movements that we continually make (about 2-3 times per second) to look around and scan our visual environment. Though we effortlessly execute saccadic eye movements all the time, they are not just ...