etd AT Indian Institute of Science: Recent submissions
Now showing items 621-640 of 9468
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Mycobacterium smegmatis topoisomerase I : insights into site specific recognition and mechanism of action
Mycobacterium smegmatis TOPOISOMERASE I: INSIGHTS INTO SITE-SPECIFIC RECOGNITION AND MECHANISM OF ACTION The work embodied in this thesis is an attempt to understand the relaxation mechanism catalyzed by Mycobacterium ... -
Functional analysis of RPB4 and RPB7 subunits of RNA polymerase II in saccharomyces cerevisiae
Eukaryotic RNA Polymerases: Roles of RPB4 and RPB7 Subunits in Saccharomyces cerevisiae Eukaryotic RNA polymerases are complex multi-subunit enzymes that play a key role in regulating gene expression in response to both ... -
Epidemiology of human rotavirus infections and structure and expression of the gene encoding the subgroup-specific antigen VP6
Rotaviruses are the leading cause of acute diarrhoea in infants and young children worldwide, causing over a million deaths annually in developing countries. Rotavirus, whose genome consists of 11 double-stranded RNA ... -
Phosphoprotein P of rinderpest virus : Its role in the virus life cycle
Phosphoprotein P of Rinderpest Virus: A Key Player in the Virus Life Cycle Introduction Negative-strand RNA viruses (NNSVs) are enveloped viruses infecting hosts across the animal and plant kingdoms. They exhibit diverse ... -
Use of formylation defective initiator tRNAs in the study of significance of formylation in initiation of protein synthesis in Escherichia coli
Initiation of protein synthesis is the major regulatory step in the translation of a messenger RNA. Initiation occurs with formylmethionine in eubacteria as opposed to methionine in archaea and eukaryotes. However, the ... -
Studies on the development of behaviour in the asiatic elephant
The present study focuses on the development of behaviour during the first year of age in the calf of the Asiatic elephant. The elephant calf can be classified as a defended follower. It is completely dependent until the ... -
Delineation of molecular events involved in Mycobacterium bovis BCG triggered expression of inducible Nitric Oxide Synthase and Nitric Oxide production : implication for Nitric Oxide mediated immune modulation
Mycobacteria are successful intracellular pathogens capable of causing both acute and chronic diseases. The ability of mycobacteria to survive within the host depends upon their effectiveness in modulating or subverting ... -
Purification, kinetic mechanism and regulation of nitrate reductase from candida utilis
Nitrate is a major source of inorganic nitrogen utilized by most plants, some algae, fungi, and a variety of bacteria. This fundamental biological process of nitrate assimilation in most systems involves the reduction of ... -
Mutational analysis of Rpb4 and Rpb7 : Insights into their role in transcription and stress response of saccharomyces cerevisiae
The Yeast Saccharomyces cerevisiae as a Model System for Stress Response and Transcription The yeast Saccharomyces cerevisiae is an excellent model system to study the molecular basis of stress response. Apart from its ... -
RNA polymerases in micor-sporum canis
Fungi are an important group of microorganisms which reproduce by means of specialized cells called spores. These spores are generally considered as a quiescent stage in their life cycle. However, on a suitable substrate, ... -
Conformation of calcium antagonists and their interaction with model membranes
Calcium antagonists are a class of drugs with diverse chemical identities and a wide range of pharmacological activities. At least four different chemical classes can be identified within this group of drugs. This heterogeneity ... -
Legume lectin carbohydrate regognition : clonning of peanut( arachits hypogea) and winged bean (psophocarpus tetragono;obus) agglutinins and reswsign of carbohydrate specificity of PNA
Recognition of cell-surface carbohydrates by lectins has wide implications in important biological processes such as protein targeting to cellular compartments, homing of lymphocytes, host-pathogen interactions, and ... -
Structure and interaction of membrane active polyene antibiotics amphotericin B and filipin
Polyene antibiotics are a group of highly unsaturated macrolide compounds. They alter the permeability of membranes of cells by displaying a selective action against organisms whose membranes contain sterols. The polyenes ... -
Molecular modelling studies on wheat germ agglutinin-saccharide interactions
Thus, the present study provides many insights into the conformational dynamics of the saccharides in vacuum and in water. It shows that at room temperature, both in vacuum and in water, the sugar ring exhibits limited ... -
Unusual DNA structures and transcription control
Structural polymorphism in DNA was envisaged from fiber diffraction studies, though all forms were initially believed to be monotonous right-handed. However, subsequent theoretical studies suggested that the DNA helix could ... -
Structural studies on peanut lectin
Lectins form a diverse group of specific carbohydrate-binding proteins of non-immune origin and are characterized by their ability to agglutinate cells. In addition to their usefulness in several applications, these proteins ... -
X-Ray studies on the structure and interactions of analgetic fenamates
Non-steroidal anti-inflammatory drugs (NSAIDs) encompass a broad spectrum of compounds with varying degrees of analgesic, anti-inflammatory, and antipyretic activity. In spite of the diversity in their chemical nature, ... -
Pseudo-periodic oscillatory dependence of rat brain voltage gated sodium channel properties on prior depolarization, studied using whole cell patch clamp, wavelet analysis and single neuron simulation
Neuronal excitability is mediated by ion-selective transmembrane ion channels, through which ions are transported in response to changes in membrane potential. In particular, the rising phase of the action potential is ... -
concanavalin A- Carbohydrate interactions: a computer modelling approach
Lectins are cell-agglutinating, carbohydrate-binding proteins. They began to generate interest when it was discovered in the 1940s that some of them were capable of specifically agglutinating human erythrocytes. Most lectins ... -
Structural investigations on mycobacterial RecA
RecA protein plays a crucial role in homologous genetic recombination, DNA repair, and SOS induction. Homologous recombination involves genetic exchange between any two DNA molecules sharing extended regions with homologous ...