etd AT Indian Institute of Science: Recent submissions
Now showing items 601-620 of 9253
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Crystal structure of low humidity monoclinic lysozyme at 1.75 Resolution
It has been demonstrated earlier in this laboratory that many protein crystals, but not all, undergo reversible structural transformations, as evidenced by abrupt changes in unit cell dimensions, diffraction pattern, and ... -
Specificity and mechanism of action of ribonuclease Ti-A computer modelling study
Enzymes recognize their substrates with very high specificity and bring about a large increase in the rates of reactions. A knowledge of the specificity and mechanism of action of enzyme-catalyzed reactions at the molecular ... -
X-ray diffraction and theoretical studies on DNA and ligand-DNA interaction.
Abstract not available -
Altered conformations in natural DNA: Studies on supercoiled form V DNA
The double helical structure of DNA proposed by Watson and Crick, which led to the development of modern biology, was assumed to be a uniform right-handed helix. However, in recent years, the sequence-dependent conformational ... -
Studies on Peptides of conformational and biological interest: chemotactic peptide analogs, acyclic cystine peptide and fragments of bacteriorhodopsin and emerimicin
Studies on the physical and conformational properties of oligopeptides have been stimulated by their widespread occurrence, impressive range of biological functions, and wide array of structural motifs. This thesis attempts ... -
B to Z transactions in synthetics polynucletides
The double helical structure of DNA proposed by Watson & Crick, which paved the way for the development of Molecular Biology, did not emphasize the importance of the sequence dependence of conformation. As a result, the ... -
Theoritical studies on the molecular structure of collagen and related polypeptides
In Section 1.5, it is seen that hydroxyproline residues can give added stability to the collagen fibers by forming both intra- as well as intermolecular hydrogen bonds involving the ?-hydroxyl group. 2.4 Conclusion It ... -
Structural kinetic and mechanistic aspects of the carboxylic ionophore mediated transmembrane cation transport
Maintenance of ionic gradients across biological membranes has been established to be achieved mainly by an interplay of two mechanisms, namely, the carrier mechanism and the channel mechanism. In the carrier mechanism, ... -
Acyclic peptides as conformational models
Proteins and polypeptides play multi?faceted functional roles in the living organism. Numerous biological processes are controlled by these biomolecules. Hence, there is widespread interest in understanding the structure, ... -
X-ray Crystallographic studies on some helical peptides containing alpha-aminoisobutyric acid
Abstract not available -
The Modes of binding of carbohydrates to concanavalin a : a computer modelling approach
Concanavalin A (Con A), the carbohydrate?binding protein (lectin) originally isolated from the jack bean (Canavalia ensiformis), specifically binds to carbohydrates containing ??D?mannose and ??D?glucose residues in ... -
Biochemical and fluorescence studies of mammalian sperm membranes
Enzymatic characterization of the sperm plasma membrane fraction by estimating the activity of a number of standard cell surface marker enzymes clearly shows that the sperm plasma membrane fraction is enriched in ... -
Flurorescence investigation of biological systems. the alamethicin transmembrane channel and model systems
Fluorescence is a technique that has been extensively utilized in the study of systems of biological relevance due to the longevity of the excited states of many molecules, which allows for a variety of physical and chemical ... -
Theoretical studies on the conformation and mode of binding of some inhibitors of thermolysin
Abstract not available -
Conformationalflexibility of DNA: Polymorphism and handness
Observation of both right- and left-helical DNA fragments in the single crystals and different poly morphous forms of DNA in fibres suggest that the con formational flexibility is inherent in the DNA mole cule. However, ... -
X-RAY CRYSTALLOGRAPHY OF SOME ANALGETIC PYRAZOLE DERIVATIVES AND FENAMATES
This thesis reports the crystal structure investigations carried out by the author on five non-steroidal anti-inflammatory, antipyretic analgesic drugs as part of an ongoing programme in this laboratory. Two of these drugs ... -
Analysis and numerical approximation of conservation laws with discontinuous
This thesis deals with an analytical as well as numerical study of conservation laws with discontinuous coefficients. We restrict ourselves to the case of single conservation laws and in one space dimension. The conservation ...