etd AT Indian Institute of Science: Recent submissions
Now showing items 521-540 of 6565
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Deciphering the role of host protein HuR in RNA virus life cycle and pathogenesis: Hepatitis C Virus and SARS-CoV-2 as exemplars.
Viruses pose a major threat to human health and the ongoing SARS-CoV-2 pandemic proves as the best evidence for that. Historically, RNA viruses have a major potential to cause such pandemics. They utilise RNA binding ... -
Studies on Δ40p53 mediated regulation of specific coding and non-coding RNAs: Consequences on cellular processes
p53 is a crucial transcriptional regulator which influences almost every possible pathway that impinges on the life of a cell. As expected of such an instrumental protein, the molecular network of p53 is as diverse as it ... -
Silk-based Biomaterials for Wound Care and Tissue Regeneration
For most individuals, wound healing is a highly organized, straightforward process. However, there are instances where external intervention becomes necessary to support the body’s innate healing mechanism. In this thesis, ... -
Optoelectronic and Magnetic Properties of 2D Layered Organic-Inorganic Hybrids and Selected Transition Metal Oxides
Perovskites with the general chemical formula ABX3 can be categorized into oxides and halides depending on the nature of the X anion. 3D organic-inorganic halide perovskites are extensively studied in the context of solar ... -
Stability of wall-bounded compressible shear flows
In this work, the linear stability of compressible shear flows in channels and pipes are studied. A steady fully-developed laminar flow of an ideal gas, driven in a channel and a pipe by a constant body acceleration, is ... -
An Investigation of Electronic Phases and Charge Dynamics in Low-Dimensional System
In condensed matter physics, the concepts of topology and symmetry are of paramount importance, particularly in understanding quantum phase transitions. Topology classifies objects based on their topological properties, ... -
Investigations on deep-level defects in HgTe nanocrystals-based photovoltaic devices using a novel instrumentation for Deep Level Transient Spectroscopy
Colloidally produced nanocrystals (NCs) arranged in thin films hold promise for next-generation semiconductors. These NCs offer tunability in semiconductor properties due to their size, shape, composition, and surface ... -
Strain engineering of 2D NEMS for resonant sensing
2D material-based nanoelectromechanical systems have emerged as excellent tools for force measurement with extreme sensitivity levels. Most sensing methods with 2D nanoelectromechanical (2D NEMS) systems utilize frequency ... -
Understanding cholesterol homeostasis and its impact on GPCR signalling in aging
Full text embargo One year up to July 2024 Aging is defined as the time-related deterioration of physiological functions necessary for survival of organisms. Despite significant progress in the extension of human lifespan ... -
Entanglement properties of gauge theories and the graviton.
Entanglement entropy is emerging as a useful quantity to study critical phenomena in quantum systems, black holes physics, and holography. In this presentation, we discuss entanglement properties of gauge theories and ... -
Ultrawideband and wide-angle scan antenna element and small active phased arrays
Wideband, wide-scan active phased arrays (APA) are widely used for multi-function radars, communication and electronic warfare. Although considerable research is available on the design and analysis of such antenna elements ... -
Development and Performance Evaluation of the Flapping Wing with In-situ Piezoceramic Actuator
Unmanned Aerial Vehicles (UAV) are essentially automatic flight vehicles having dimensions, wingspan and airspeed, smaller than the conventional aerial vehicles. UAVs are employed widely in applications such as surveillance ... -
Molecular pathways governing maturation and decay of precursor piRNAs in Caenorhabditis elegans
Piwi-interacting RNAs (piRNAs) are an animal-specific class of germline-enriched small non-coding RNAs that play a crucial role in germline development and fertility in diverse organisms. In Caenorhabditis elegans (C. ... -
Bayesian implicit filters for the analysis of numerically stiff structural dynamic state space models
This thesis reports on combined experimental and computational investigations conducted on problems of state and combined state and parameter estimation applied to vibrating engineering structures. The standard dynamic ... -
Elucidating the role of SNARE Syntaxin 1A in regulating lysosome and melanosome function
SNAREs are transmembrane proteins that localize to specific membranes and facilitate the process of membrane/vesicle fusion. SNAREs mediate the fusion by binding with their respective cognate SNAREs. SNAREs mediate the ... -
On some canonical metrics on holomorphic vector bundles over Kahler manifolds
This thesis consists of two parts. In the first part, we introduce coupled Kähler- Einstein and Hermitian-Yang-Mills equations. It is shown that these equations have an interpretation in terms of a moment map. We identify ... -
Exponential Resummation of QCD at Finite Chemical Potential
A comprehensive study of the QCD phase diagram is one of the challenging and open problems in high energy physics. Having significant astrophysical implications, this is also important in constructing the chronological ... -
Characterization of Neuroprotective Reactive Astrocytes in the Aging Mammalian Brain
The brain manifests cognitive deficits in aging and becomes more vulnerable to neurodegeneration. Astrocytes play several critical roles in the brain, including synapse formation, maturation, elimination, and synaptic ... -
Improved Methods for Filtration, Drainage and Structural Evaluations With and Without Geocomposites for Subsurface Drainage of Pavements
Pavements are continuously exposed to the environment leading to ingress of water from multiple sources that structurally weakens the pavement materials. The conventional solution for drainage requires granular material ... -
Isolation, structure elucidation and increasing anticancer efficacy of an anti-cancer secondary metabolite from a marine-derived endophytic fungus, Aspergillus species
Cancer is the leading cause of mortality globally, contributing to ~10 million fatalities in 2020, or roughly one in every six deaths, according to global cancer statistics 2020. Around 50% of all small molecules approved ...