etd AT Indian Institute of Science: Recent submissions
Now showing items 421-440 of 9078
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Studies on novel structural motifs using synthetic oligodeoxyribonucleotides
The double helical structure of DNA proposed by Watson and Crick was once thought to be rigid and monotonous in structural terms. Although the inherent conformational flexibility in DNA was envisioned through theoretical ... -
Structucture function realtionship of winged bean basic agglutin (WBA I): carbohydrate binding, Domain structure and amino acid sequesnce analyses
The thesis deals mainly with the following aspects of Winged bean (Psophocarpus tetragonolobus) basic agglutinin (WBA I): i) Thermodynamic studies on the binding of WBA I with various blood group A and B reactive sugars ... -
Studies on the DNA binding and specificity of some synthetic non intercalotors
The DNA binding behaviour of netropsin (Nt) and distamycin-A (Dst-A) has been the subject of intense investigation in recent years. Nt and Dst-A belong to a class of oligopeptide antibiotics possessing two or three ... -
X-ray differaction studies on belladonna mottle virus at 3.8 A resolution
Tymoviruses are a group of highly infectious plant viruses found in several geographical locations. The type member of this group of viruses, turnip yellow mosaic virus, has been studied in detail regarding its architecture, ... -
Conformation of peptidoglycan and mode of penicillin action
Penicillins and cephalosporins are conformationally similar to D-L-Ala-D-Ala due to the presence of the lactam ring. The mode of binding of the aminoacyl group of penicillin and cephalosporin with transpeptidase is the ... -
Crystal structure of low humidity monoclinic lysozyme at 1.75 Resolution
It has been demonstrated earlier in this laboratory that many protein crystals, but not all, undergo reversible structural transformations, as evidenced by abrupt changes in unit cell dimensions, diffraction pattern, and ... -
Specificity and mechanism of action of ribonuclease Ti-A computer modelling study
Enzymes recognize their substrates with very high specificity and bring about a large increase in the rates of reactions. A knowledge of the specificity and mechanism of action of enzyme-catalyzed reactions at the molecular ... -
X-ray diffraction and theoretical studies on DNA and ligand-DNA interaction.
Abstract not available -
Altered conformations in natural DNA: Studies on supercoiled form V DNA
The double helical structure of DNA proposed by Watson and Crick, which led to the development of modern biology, was assumed to be a uniform right-handed helix. However, in recent years, the sequence-dependent conformational ... -
Studies on Peptides of conformational and biological interest: chemotactic peptide analogs, acyclic cystine peptide and fragments of bacteriorhodopsin and emerimicin
Studies on the physical and conformational properties of oligopeptides have been stimulated by their widespread occurrence, impressive range of biological functions, and wide array of structural motifs. This thesis attempts ... -
B to Z transactions in synthetics polynucletides
The double helical structure of DNA proposed by Watson & Crick, which paved the way for the development of Molecular Biology, did not emphasize the importance of the sequence dependence of conformation. As a result, the ... -
Theoritical studies on the molecular structure of collagen and related polypeptides
In Section 1.5, it is seen that hydroxyproline residues can give added stability to the collagen fibers by forming both intra- as well as intermolecular hydrogen bonds involving the ?-hydroxyl group. 2.4 Conclusion It ... -
Structural kinetic and mechanistic aspects of the carboxylic ionophore mediated transmembrane cation transport
Maintenance of ionic gradients across biological membranes has been established to be achieved mainly by an interplay of two mechanisms, namely, the carrier mechanism and the channel mechanism. In the carrier mechanism, ... -
Acyclic peptides as conformational models
Proteins and polypeptides play multi?faceted functional roles in the living organism. Numerous biological processes are controlled by these biomolecules. Hence, there is widespread interest in understanding the structure, ... -
X-ray Crystallographic studies on some helical peptides containing alpha-aminoisobutyric acid
Abstract not available -
The Modes of binding of carbohydrates to concanavalin a : a computer modelling approach
Concanavalin A (Con A), the carbohydrate?binding protein (lectin) originally isolated from the jack bean (Canavalia ensiformis), specifically binds to carbohydrates containing ??D?mannose and ??D?glucose residues in ... -
Biochemical and fluorescence studies of mammalian sperm membranes
Enzymatic characterization of the sperm plasma membrane fraction by estimating the activity of a number of standard cell surface marker enzymes clearly shows that the sperm plasma membrane fraction is enriched in ... -
Flurorescence investigation of biological systems. the alamethicin transmembrane channel and model systems
Fluorescence is a technique that has been extensively utilized in the study of systems of biological relevance due to the longevity of the excited states of many molecules, which allows for a variety of physical and chemical ...