etd AT Indian Institute of Science: Recent submissions
Now showing items 201-220 of 9405
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Structure-function relationships of physalis mottle virus (PhMV) replicase
Physalis mottle virus (PhMV) belongs to the tymovirus group of (+)strand plant viruses that infect solanaceous plants. Its icosahedral protein shell is made up of 180 identical protein subunits, each of Mr 20 kDa. The ... -
studies on chicken riboflavin carrier protein : Recombinant expression and receptor characterization
Investigations detailed in this thesis constitute part of an ongoing research programme in our laboratory on riboflavin carrier protein (RCP), with particular reference to recombinant expression of chicken RCP in E. coli ... -
Studies on the regulation of progesterone biosynthesis in the human placenta
The placenta is a multifunctional, ephemeral organ that develops during mammalian pregnancy as an association between fetal and maternal tissues. It performs a wide variety of functions to protect and nourish the fetus ... -
Identification and characterization of meiotic DNA repair sites of rat pachytene spermatocytes
Abstract Not Available -
Mechanism of interaction of carbonyl-directed reagents at the active site of sheep liver serine hydroxymethyltransferase
SHMT catalyzes the first step in the pathway for the interconversion of folate coenzymes. In this reaction, Ser is converted to Gly and the hydroxymethyl group of Ser is transferred to Hfolate to yield 5,10CHHfolate. SHMT ... -
Anti-DNA antibodies in systemic lupus erythematosus and their induction in mice
Autoantibodies capable of binding to DNA are present in significantly high levels in patients with systemic lupus erythematosus (SLE). The origin of these autoantibodies is still unresolved, but it is generally accepted ... -
Investigations on the reactions of vitamin B6 in model systems : syntheses and structural studies on metal complexex of vitamin B6- related compounds
It has been postulated that in aqueous solution PN exists in the zwitterionic form; however, PN is converted to the nondipolar form in dioxane and alcohols. In the crystalline state also, free PN exists in the nondipolar ... -
Biochemical and Immunological studies on methyl isocyanate exposure
Following the release of the contents of Methyl isocyanate (MIC) storage Tank No.610 at Union Carbide India Ltd., Bhopal, on December 2-3, 1984, a number of scientific investigations were initiated to understand the acute ... -
Serine hydroxymethyltransferase fro, mung bean (Vigna radiata) Seedling : a new pyruvoyl enzyme
Abstract Not Available -
Gene for the major antigenic protein of foot and mouth desease virus, type ASIA 1 63/72
Foot and Mouth Disease Virus (FMDV) contains a positivesense singlestranded RNA enclosed in a protein capsid composed of four structural proteins: VP1, VP2, VP3, and VP4. VP1 is the major antigenic protein, and variations ... -
Immunochemical studies on riboflavin carrier proteins.
Investigations detailed in this thesis constitute a part of a continuing programme of research undertaken in this laboratory on riboflavin carrier proteins (RCPs), with particular reference to the production and characterization ... -
Uncovering the Role of Mitochondrial Co-chaperones and Artificial Antioxidants in Cellular Redox Homeostasis
Mitochondria play a multidimensional role in cellular physiology, including apoptosis, stress response, and metabolism. Although mitochondria contain their own DNA, most mitochondrial proteins are nuclear-encoded and ... -
Role of mitochondria in cancer: G-quadruplex structures at fragile regions of the mitochondrial genome and a novel mode of BCL2 inhibition in cancer therapeutics
Mitochondrial functions are supported by proteins encoded by both the mitochondrial genome and several nuclear-encoded proteins targeted to mitochondria. Mutations affecting mitochondrial functions lead to cellular ... -
Mechanism of DNA double-strand break repair: Biochemical characterization of classical NHEJ and microhomology mediated alternative DNA end Joining.
Maintenance of genomic integrity and stability is essential for organismal survival. DNA damage can occur in the form of base modifications, single-strand breaks (SSBs), and double-strand breaks (DSBs). Among these, DSBs ... -
Mechanism and regulation of physiological and pathological roles of RAG complex: Implications in lymphoid malignancies and immunosuppression
The Recombination Activating Gene (RAG) complex, consisting of RAG1 and RAG2, is the enzyme responsible for generating antigen receptor diversity, enabling the vertebrate adaptive immune system to respond to a vast array ...