etd AT Indian Institute of Science: Recent submissions
Now showing items 1941-1960 of 6964
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Solution structures and conformational isomerism of novel conopeptides from Indian marine cone snails
This thesis describes the structure determination of peptides found in marine cone snails’ venom at atomic resolution and their biological activity. Chapter 1 gives a brief introduction to the cone snails, conopeptides, ... -
Ageing associated altered host response to bacterial infection
Chapters in which I have elucidated and elaborately described how senescence alters the cellular response to infection, here I demonstrate how senescence in multiple tissues simultaneously contribute to pathogen spread and ... -
Multiple routes to tackling drug-resistant tuberculosis: Systems modeling to unravel resistance mechanisms, drug combinations, and novel host-based biomarkers
Tuberculosis (TB) has been a major public health problem. The successful treatment of TB requires long-term (6-months) multi-drug chemotherapy, but poor patient compliance and non-adherence lead to the evolution of ... -
Stop codon readthrough in MTCH2 mRNA and its role in mitochondrial physiology
Stop codon readthrough is the process in which translation continues beyond a stop codon till a downstream, in-frame stop codon generating a polypeptide with a C-terminal extension. MTCH2 was selected as a potential ... -
Studies on Soluble Lead Redox Flow Battery
Redox flow batteries (RFBs) offer an opportunity to make renewable energy storage more affordable and could accelerate prospects for utility-scale development of solar/wind energy storage. RFBs can be almost instantly ... -
Functional regulation of cytoplasmic dynein in vivo
In the crowded confines of the eukaryotic cell, where large cargo (> 100 nm) are diffusionaly constrained, intracellular transport by motor proteins plays a crucial role in the exchange of material between various compartments ... -
Territorial and mating strategies of males in a lekking population of blackbuck Antilope cervicapra
Territoriality associated with lek-mating systems is unique in that males defend small, heavily clustered territories that lack resources usually thought to attract females, such as food and water. Females visit these male ... -
Representations of Special Compact Linear Groups of Order Two : Construction, Representation Growth, Group Algebras and Branching Laws
Let o be the ring of integers of a non-Archimedean local field such that the residue field has characteristic p: Let p be the maximal ideal of o: For Char¹oº = 0; let e be the ramification index of o: i.e., 2o = pe: Let ... -
A Phylogenetic Perspective on The Phytogeography of Western Ghats
I used a finer scale data of 156 published plots across the entire latitudinal range of WG, covering most of the protected forests. The pruned phylogeny for this study consisted of 367 species, of which ~ 50% are taxa endemic ... -
CcdB : Stability, folding and application to design novel antibacterials
The primary amino acid sequence typically dictates the ultimate conformation of the protein. Mutations in the sequence demonstrate neutral, positive or negative effects on the structure-function relationship of the protein. ... -
Multiscale Modeling of Quantum Transport in 2D Material Based MoS Transistors
Atomically thin 2D materials have ushered in a new era in the fi eld of nano-science and tech- nology and have been translated to notable advancements in the design of sensors, optoelectronic devices, exible electronics. ... -
Investigation of RAG1 in lymphoid and brain cells: Understanding mechanism and regulation
In summary, we show that RAG1 expression is regulated through a novel miRNA (miR- 29c) mediated mechanism and establish that as an additional mode of RAG1 regulation. Studies described in the thesis reveal that among the ... -
Microstructure and texture evolution in wire drawing and its role on the tension and torsion response of nickel microwires
It is now well known that the strength of the metallic materials depends on microstructural features such as dislocation density, grain size, and precipitates. The migration of lattice defects such as dislocations is a ... -
Experiences in using Reinforcement Learning for Directed Fuzzing
Directed testing is a technique to analyze user-specified target locations in the program. It reduces the time and effort of developers by excluding irrelevant parts of the program from testing and focusing on reaching ... -
Achieving Fairness in the Stochastic Multi-Armed Bandit Problem
The classical Stochastic Multi-armed Bandit (MAB) problem provides an abstraction for many real-world decision making problems such as sponsored-search auctions, crowd-sourcing, wireless communication, etc. In this work, ... -
Some results on Spectral spaces and Spectral sequences
This thesis is made up of two independent parts. We begin the first part by showing that the collection of all prime ideals of a monoid or, in other words, the spectrum of a commutative monoid, endowed with the Zariski ... -
Interactions between host cellular factors and Rotaviral viroplasmic non-structural proteins NSP5, NSP2 and their influence on virus replication
Overall, the present study demonstrates the dynamic nature of rotavirus viroplasm and how it manipulates the intracellular environment by intracellular relocalization of host proteins and their sequestration in viroplasms ... -
At-site and Multisite Probabilistic Forecasting of Streamflow
Streamflow forecasts are very useful for a variety of applications such as flood warning, reservoir operation and water resources planning and management, especially in countries like India where streamflow can be highly ... -
Studies on switching of J and H aggregates in Donor-Acceptor molecular materials
The aggregation of molecular materials plays a central role in determining their functional properties. In the aggregated state, conjugated chromophores may exhibit enhanced emission, in comparison to their dilute ... -
Pathogen-derived volatiles modulate flight or fight response in Caenorhabditis elegans
In nature, the interaction between two organisms largely relies on their ability to sense and respond to each other, which involves many specific chemicals and signaling pathways. Animals have evolved mechanisms to detect ...