etd AT Indian Institute of Science: Recent submissions
Now showing items 1021-1040 of 6860
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HYDRA: A Dynamic Approach to Database Regeneration
Database software vendors often need to generate synthetic databases for a variety of applications, including (a) Testing database engines and applications, (b) Data masking, (c) Benchmarking, (d) Creating what-if scenarios, ... -
Understanding the role of paraspeckle components NEAT1 and PSPC1 in HCV life cycle and pathogenesis
Hepatitis C virus (HCV) is an enveloped, small, icosahedral, positive-sense single-stranded RNA virus that belongs to the Hepacivirus genus and the Flaviviridae family. HCV causes acute and chronic hepatitis which can range ... -
Transcriptional regulation of a microRNA encoding gene MIR319C during leaf development in Arabidopsis thaliana
The evolutionarily conserved microRNA miR319 and its target transcription factors encoded by five CIN-TCPs (TCP2, 3, 4, 10 & 24) regulate leaf morphogenesis in Arabidopsis by triggering the division to differentiation ... -
2,3-Dideoxy Sugars in Glycoconjugations and Cyclic Oligosaccharide Synthesis
2,3- Dideoxy sugars are versatile synthons for organic synthesis. The applications are diverse in biological systems and organic synthesis. In the first part of the thesis, 2,3-unsaturated sugars are used for the ... -
Exploring the Fundamental Limits of Information-Theoretically Secure Key Generation and DNA-Based Data Storage
In this dissertation, we carry out an exploration of the fundamental limits of information-theoretic security in two different settings: multiterminal key agreement and DNA-based data storage. Most of the dissertation ... -
Quantized heat flow probing thermal equilibration and edge structures of quantum Hall phases in graphene
In condensed matter physics, usually, phases are described using Landau’s approach, which characterizes the phases in terms of underlying symmetries that are spontaneously broken. Over the past few decades, a different ... -
Detection of charge-neutral modes to spin-wave excitations in graphene quantum Hall, and periodic magnetic field effect on Dirac electrons
In the quantum Hall (QH) regime, the electrical transport happens along the downstream chiral edge modes (dictated by the external magnetic field) while the bulk remains a vanilla insulator. However, it has been theoretically ... -
Deciphering the mechanisms employed by Salmonella to mediate modulation of host endo-lysosomal machinery
Salmonella genus encompasses Gram-negative, rod-shaped, facultative anaerobic, non-sporulating, and predominantly motile enteric bacteria. It causes pathogenesis in a wide array of hosts, from cold-blooded animals to humans ... -
Investigation of twisted bilayer graphene using electrical and thermoelectric transport
The ability to tune the twist angle between di erent layers of two-dimensional materials has opened up a new dimension to band engineering in van der Waals (vdW) heterostructures. By taking advantage of the formation of ... -
Post translational modification and DNA binding studies with two nucleoid associated proteins of Mycobacterium tuberculosis
Genome in prokaryotes is found in a small confinement called nucleoid. The nucleoid compaction is brought about by the combined action of topoisomerases and Nucleoid associated proteins (NAPs). Topoisomerases maintain ... -
Understanding the architecture of mitochondrial presequence translocase machinery and its implications in ALS progression
The current thesis describes the structural organization of the presequence translocase machinery and its functional association with ALS pathogenesis. The TIM23 complex is essential for the mitochondrial biogenesis of ... -
Experimental Investigation of Novel High Shear Injector at Elevated Pressure Conditions: Hydrodynamics, Spray and Combustion Characterization
The stringent pollution and emission norms due to the present climate change and global warming have pushed industries to meet these norms and cut down their emission levels. In the same pipeline, the aviation industries ... -
On Hypergeometric solutions of Feynman integrals using Mellin-Barnes Integrals with Applications
Experimental measurements of physical observables in particle colliders rely on high-precision theoretical calculations to validate the predictions of any theoretical model and detect signals of new physics. These theoretical ... -
Microscopic Analysis of Self Healing Circuits Using Image Processing
Open circuit faults are common circuit failure mechanism in Thin Film Transistor (TFT) integrated circuits or Printed Circuit Boards (PCBs). Thin film Transistors are widely used in flexible electronics and are ... -
Carbon Dots for Next-generation Artificial Lighting Devices
Energy conservation has become a major concern globally in today’s world and artificial lighting (AL) accounts to ~50% of total energy consumption. With increase in population accompanied by modern civilization there is a ... -
Design and Development of a Semi-automated System for Electro-thermo-mechanical (Etm) Phenotyping of Breast Tissues Ex-vivo
Breast cancer currently accounts for 25% of all cancers diagnosed in women globally. The conventional confirmatory diagnosis of breast cancer involves histological analysis using hematoxylin and eosin (H&E) staining, ... -
Drilling Damage in Laminated Polymer Matrix Composites Considering Thermal Efefcts: Experimental and Numerical Analysis
In the present work, drilling induced damage in multi-directional carbon fiber reinforced polymer (MD-CFRP) laminates has been investigated by experimental and numerical approaches. Exit-ply delamination during drilling ... -
Investigating the role and regulation of Polypyrimidine tract binding protein (PTB) in isoform switching during muscle development in Drosophila melanogaster
Muscles are an excellent system to dissect the development, physiology and evolution of cell heterogeneity and isoform switching. The vertebrate skeletal muscles are composed of heterogeneous muscle fibres. These fibres ... -
Vaned Diffuser Effect on Centrifugal Compressor Performance and Stall
A centrifugal compressor is a mechanical device that helps to achieve higher pressure ratios at lower mass flow rates. It is used in many applications such as turbochargers, cruise missiles, and turbojet engines where ... -
Elucidating the Role of Cyclic GMP in Diarrhoea and Intestinal Inflammation
Cyclic guanosine 3’,5’-monophosphate (cGMP) performs a wide range of functions in various cell types and tissues. The cellular levels of cGMP are maintained by the enzymatic conversion of guanosine 5’-triphosphate (GTP) ...