etd AT Indian Institute of Science: Recent submissions
Now showing items 1001-1020 of 6863
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Substrate interrogation of the CRISPR-Cas12a endonuclease reveals an unexpected functional plasticity
Substrate interrogation of the CRISPR-Cas12a endonuclease reveals an unexpected functional plasticity Currently, Cas9 and Cas12a (also known as Cpf1) are the sole members of a large family of RNA-guided nucleases that ... -
Fast Methods for Modelling and Simulation of Fully Integrated Voltage Regulators in Microprocessors
Fully Integrated Voltage Regulators (FIVR) have been introduced in the latest generation of high-performance server microprocessors to improve the performance and power efficiency of the processors. FIVR is a switched ... -
Experimental study of the flow of granular media through a horizontal screw feeder system
A significant fraction of the materials handled in the chemical, food-processing, and pharmaceutical industries are particulate in nature. Screw feeder systems are often employed in such scenarios to achieve their bulk ... -
Mesonic screening mass at zero and finite chemical potential
The finite temperature analysis of QCD is challenging since perturbation theory is not applicable in that regime. A non-perturbative method like lattice QCD is thus required to obtain an estimate of the necessary observables. ... -
A study of extracellular matrix dynamics in epithelial cancer progression with a special focus on ovarian cancer spheroidogenesis
Epithelial ovarian cancer (EOC) is one of the most debilitating gynecological cancers in women worldwide due to its insidious symptoms. The predominant subtype of ovarian cancer: high-grade serous ovarian carcinoma (HGSOC), ... -
Towards the Development of MEMS g-Switches
Accelerometers are sensors that measure and record the acceleration of an object in motion. They typically contain spring and mass elements that are set into vibration upon any impressed acceleration. The characteristics ... -
Assessment and Monitoring Of Hydrometeorological Variables And Extreme Conditions for Present and Future Climate Change Scenarios
Monitoring and assessment of Hydrological/hydrometeorological Variables (HVs) like streamflow, soil moisture, precipitation, and temperature are essential for various applications such as prediction/forecasting of natural ... -
Investigations on Generation of Multilevel 24-Sided Polygonal Voltage Space Vector Structures Without Vector Averaging for Variable Speed Drives
Induction motors are mainly powered by two-level inverters in low-voltage, low-power drive applications. For medium and high voltage applications, a conventional two-level inverter needs high voltage rated switches, ... -
Exploring the role of low complexity protein sequence in regulating RNA granule dynamics and translation control
RNA granules are conserved membraneless mRNP complexes that play an important role in determining mRNA fate by affecting translation repression and mRNA decay. Processing bodies (P-bodies) harbor enzymes responsible for ... -
Optimal Placement and Traffic Steering of VNFs and Edge Servers using Column Generation in Data Center Networks
Telecom Service Providers (TSPs) were traditionally dependent on physical devices to provide end-to-end communication. The services provided were high quality and stable but low in agility and hardware-dependent. As the ... -
On Plug-and-Play Regularization using Linear Denoisers
The problem of inverting a given measurement model comes up in several computational imaging applications. For example, in CT and MRI, we are required to reconstruct a high-resolution image from incomplete noisy measurements, ... -
INTERPIN: identifying INtrinsic transcription TERminators, hairPINs in bacteria
The conversion of DNA to RNA through transcription is an important step in the life cycle of every organism. It ensures that the genetic information in DNA is converted through RNA into instructions/blueprints for the ... -
Understanding the role of mtHsp70 in regulating mitochondrial homeostasis: revealing its significance in Congenital Sideroblastic Anemia progression
Mitochondria are ubiquitous organelles placed at the nexus of several metabolic and signaling pathways essential for cell survival. Therefore, maintaining a healthy and functional organelle becomes paramount for the cell. ... -
Multi-vehicle anticipation-based models for describing driver behaviour in heterogeneous and disorderly traffic conditions
Driver behaviour models are widely used in the traffic engineering literature and practice. They are used for understanding drivers’ manoeuvring decisions in traffic streams. They also form the building blocks of microscopic ... -
Edible Battery Design for Bio-Medical applications
This thesis is focused on the development of digestible electronics for healthcare. The vision is the development of an edible pill that performs diagnosis inside the body. Any such edible device needs an energy source ... -
Design and development of lateral force-controlled tribosystems
In a tribo-system, the frictional resistance during a sliding process depends on several parameters. These parameters include the interacting materials, their surface topography, contact conditions such as normal load, ... -
Unraveling the multifaceted interactions between the tumor cell hierarchy and the stroma: Implications on tumor growth
In this study, we have functionally characterized the roles of SEZ6, a GSC-specific protein, and FMOD, a DGC-specific protein, in inducing tumor angiogenesis. Angiogenesis being a crucial requirement for both tumor initiation ... -
Cerium Oxide-based Degradable Polymer Nanocomposites for Bone Tissue Engineering
The incidences of bone-related disorders is growing steeply worldwide because of acute trauma, diseases related to aging, and obesity. Bone has a natural regenerative capacity to repair and regenerate fractures and small ... -
An Investigation of the Characteristics of Monsoon Low Pressure Systems in the Present Climate and their Sensitivity to Topography and Climate Change
Monsoon Low-Pressure Systems (LPS) are synoptic-scale tropical disturbances that periodically form over the Indian subcontinent during the summer monsoon season (June-September). Apart from being a lifeline to agriculture, ... -
Insights into mRNA recruitment by eukaryotic initiation factor 4 during translation in Saccharomyces cerevisiae
Ribosomes are responsible for synthesizing proteins in the cells by using mRNA as the template. However, the ribosomes cannot perform this function without the help of other protein factors. Different factors are required ...