etd AT Indian Institute of Science: Recent submissions
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Structure and function of aspartic proteinases
Crystallographic and Computational Studies on Aspartic Proteinases: Structural and Functional Insights Abstract and Synopsis Chapter 1 - Introduction Aspartic proteinases are a superfamily of enzymes involved in diverse ... -
Genes involved in cell type specification and morphogenesis in Dictyostelium discoideum
Calcium-Dependent Regulation of Gene Expression and Morphogenesis in Dictyostelium discoideum Abstract and Synopsis Introduction Differentiation and morphogenesis occur in concert to ensure the development of multicellular ... -
Genetic analysis of activation and silencing of the cryptic bgl operon of Escherichia coli
Activation and Silencing of the bgl Operon in Escherichia coli: Genetic and Physiological Perspectives Abstract and Synopsis Introduction The bgl operon of E. coli is one of four genetic systems in Enterobacteriaceae for ... -
Transforming growth factor-B5 promoter regulation : role of MyoD and Nkx2.5 transcription factors
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Graph theoretical studies on protein structure, folding and stability
Graph Spectral Analysis of Protein Structures: Insights into Folding, Stability, and Function Abstract and Synopsis Introduction Efficient analysis of protein 3D structures provides insights into their function, folding, ... -
Molecular analysis of B-glucoside utilisation in klebsiella aerogenes
Genetic Organization and Regulation of -Glucoside Utilization Genes in Klebsiella aerogenes Abstract and Synopsis Introduction The plant-derived aromatic -glucosides salicin (Sal) and arbutin (Arb), along with cellobiose ... -
Family of G-Proteins : Survey in Genomes, Structural Comparisons and Modelling(ptA)
A protein being assigned to a family does not immediately imply that it will function as a typical member of that family. It only suggests that the protein can be associated with the family based on sequence similarity. ... -
Insights into signal transduction by the guanylyl cyclase C receptor : Role of ATP and tyrosine phosphorylation
Signal Transduction Mediated by Guanylyl Cyclase C: Regulation by ATP and Tyrosine Phosphorylation Introduction All living cells respond to extracellular signals by generating specific cellular responses through signal ... -
Studies on the expression on transforming growth factor-Beta isoforms in the hamster uterus : Regulation by steroid homones
In conclusion, cellular' localization supports autocrine and/or paracrine roles for most of the growth factors examined. Their stage-specific expression during estrous cycle and pregnancy indicate the role of steroid ... -
Electrophysiological study of veratridine-modified rat brain type IIA sodium channels and their interactions with open channel blocking compounds
Alkaloid toxins affecting electrical excitability have been known for about a century, with articles by Sydney Ringer describing their effects appearing in the first volume of the Journal of Physiology. Yet, the molecular ... -
Studies of immunoreactive riboflavin carrier protein in malegerm cells in the golden hamster
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Xenopus laevis transforming growth factor-beta 5 (TGF-BETA 5) : characterization of the promoter and regulation of gene expression
Investigations detailed in this thesis constitute research work undertaken in our laboratory on Transforming Growth Factor5 (TGF5), with particular reference to determining the gene structure, characterizing the promoter, ... -
Protein structure, stability and dynamics in ribonuclease S
The process of protein folding involves the transition of a sequence of amino acids in an unfolded polypeptide chain to a unique folded state, called the native state of the protein. Understanding protein folding requires ... -
Computational studies on structure and stability of proteins
Accessibility has long been used to measure the burial of protein residues. However, this procedure fails to precisely indicate how deep a residue lies from the surface, because two residues with the same accessibility can ... -
Model building and molecular mechanics studies on G-Tetraplex and B-Z-B DNA motifs
For almost 25 years following the proposal of the doublehelix structure by Watson and Crick, this model was believed to be the only structure for DNA. Even though various polymorphic forms such as A, B, C, and D were ... -
Characterization of ligand binding in ribonuclease a computer modelling and simulation approach
In recent times, the fields of biochemistry, molecular biology, structural studies, and biomolecular computation have moved closer to each other and are now interconnected. Often, the inputs from one discipline can serve ... -
Molecular dynamics simulations of RNase A-ligand interactions and RNase S mutants
Thus, the simulations of 100 ps each of RNase A and RNase S at temperatures of 300 K and 330 K indicate similar dynamic behaviour about their timeaveraged structures. An exhaustive analysis of data from the simulations ... -
Conformation and ion-binding properties of cyclic and bicyclic peptides
The structure-function relationship of biomolecules is one of the important problems in modern biology and can be understood to a large extent by investigating the conformational aspects of biomolecules with biological ... -
Conformational search of cyclic ionophores & characterization of proline helices with constraints by molecular dynamics studies
It has been found that valinomycin assumes a variety of conformations depending on the environment. Its ability to selectively complex with K ions and transport them through the membrane is related to its ability to adopt ... -
Conformational Studies On Globular Proteins : An Alpha-Carbon Based Algorithm For Identifying Secondary Structures
The foregoing sections of this chapter provided an introduction to the conformational study of polypeptide chains and described the general features of the structure of globular proteins. The conformation of the side chains ...