etd AT Indian Institute of Science: Recent submissions
Now showing items 1-20 of 6450
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Investigating the maintenance of X- chromosome inactivation in extra-embryonic endoderm and epiblast stem cells
In eutherian female mammals, one of the X-chromosomes gets inactivated to compensate for the expression dosage of X-linked genes between the sexes. X-chromosome inactivation (XCI) serves as a paradigm of epigenetic memory ... -
Investigations on Radial Inflow Turbine for Supercritical CO2 Power Cycles
Potential of using supercritical CO2 (sCO2) as a working fluid for the next generation of thermal power plants is being actively pursued by researchers across the world. CO2 has a critical temperature of 31.1 °C and a ... -
On existence and regularity of some complex Hessian equations on Kahler and transverse Kahler manifolds
The thesis consists of two parts. In the first part of the thesis, we classify the convergence behaviour of rotationally symmetric solutions to the modified J-flow on the blow-up of the complex projective space at a ... -
On Topological Approaches for Planning of Electro-Mechanical Assemblies
Assembly planning pertains to the process of creating a complete plan for fabricating the product from its constituent parts, considering the final product geometry and resources available at the manufacturing facility. ... -
The role of neuronal integrity in maintaining gut functions and homeostasis
This thesis investigates two main aspects of neuronal integrity and gut health. Firstly, it examines the intricate relationship between neuronal integrity and the maintenance of gut homeostasis in Drosophila melanogaster. ... -
On regular subalgebras of symmetrizable Kac-Moody algebras and related combinatorics
In this thesis, we study two aspects of Kac-Moody algebras. One is to understand the subalgebras that can be embedded inside a Kac-Moody algebra as subalgebras generated by real root vectors. The other one is to explicitly ... -
Mixed Variational Approaches in Nonlinear Continuum Mechanics and Discretization by Finite Element Exterior Calculus
Numerical solution techniques for nonlinear elasticity have been an active area of research for a while. Right from the early days, it was recognized that constructing well-performing FE approximations for nonlinear ... -
Structural and functional characterization of human regulator of telomere elongation helicase 1 (RTEL1)
RTEL1 is an ATP-dependent DNA helicase that translocates on the single-stranded DNA (ssDNA) from 5′ to 3′ direction. It is an iron-sulfur (Fe-S) cluster and DEAH motif-containing helicase. RTEL1 has been shown to play ... -
Understanding the mechanism of host deacetylase SIRT1 and SIRT3 in the modulation of Salmonella pathogenesis
Host sirtuins are one of the important modulators of host immuno-metabolic regulation. However, the role of sirtuins in the modulation of the immune metabolism pertaining to Salmonellosis is largely unknown. Here, we ... -
Operationalising Sustainability in Smart Manufacturing Systems: A Model-Based Approach
This dissertation addresses the need for sustainability in manufacturing industries by leveraging digitalization and Model-Based Systems Engineering (MBSE). The research presents a comprehensive framework for operationalizing ... -
Multistability in cellular differentiation enabled by three and four node mutually repressive regulatory networks: A case study of CD4+ T-cell decision making
Cellular differentiation is controlled by the complex dynamics of gene regulatory networks (GRNs), often featuring multistability, where multiple stable states represent different phenotypes. A common example is the toggle ... -
Sequence Alignment to Cyclic Pangenome Graphs
The growing availability of genome sequences of several species, including humans, has created the opportunity to utilize multiple reference genomes for bioinformatics analyses and improve the accuracy of genome resequencing ... -
Modelling and evaluation of nitrate transit times in groundwater systems
Transit time distribution is one of the fundamental descriptors of flow and transport behavior of catchments. Intensification of agriculture and consequent anthropogenic inputs of nitrate rich fertilizers in agricultural ... -
Advancements in Microcantilever Sensor Technology: Gas Sensing Application
Micro and nanoelectromechanical systems (M&NEMS) have great potential in sensor technologies, which are used for detecting mass or gas, measuring force and acceleration, and in applications related to memory storage and ... -
Advanced Architectures for Cascaded Raman Fiber Lasers
Fiber lasers have exhibited significant expansion in their diverse applications within the fields of communications, industrial operations, defence, and the medical sector. They require a rare earth doped element as ... -
Design of Immunogens Derived from the Conserved Stem of Influenza Virus Hemagglutinin
Embargo up to 15/7/2025 -
Synthesis and Applications of Unusual Self-assembled Coordination Architectures
Biological systems like enzymes have complex structures which help in executing intricate chemical reactions. Endeavoring to replicate such chemical reactions, chemists have crafted discreate molecular structures ... -
Fabricating Physical and Robotic Systems to Investigate Collective Behavior
The motion of particles has always been fascinating for scientists. We, as scientists, try to decode the mysteries of motion of massive objects like black holes, stars, and planets to objects nearly void of mass such as ... -
Gallium Oxide Vertical Power Devices - Modeling, Material Growth, and Hetero-epitaxial Integration with Silicon
𝛽-Ga2O3 is a candidate for a new generation of power semiconductors that can significantly lower the conduction losses and increase power density in the power converters. PFOM or power figure of merit (V2Br/Ron) is a ratio ... -
Development of an Intraoperative Probe for Brain Tumour Delineation Combining Multimodal Tissue Characterization and Soft-Robotics
Accurate identification of surgical margins in brain tumors is of significant prognostic importance. Despite the availability of 5-ALA and image guidance methods, recognizing tumor boundaries is highly subjective, dependent ...