etd AT Indian Institute of Science: Recent submissions
Now showing items 1-20 of 7572
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Mechanistic insights into the recruitment of viral type 2 IRES to ribosomal pre-initiation complex and its interaction with eIF4 factors and PTB1
Viruses often employ internal ribosome entry sites (IRESs) in their genomic RNA to hijack the host’s translational machinery. The IRES elements are characterized by unique secondary and tertiary RNA structures capable of ... -
Achieving oral bioavailability of therapeutic macrocyclic peptides by bridging backbone chemistry with pharmacokinetics
Full text embargo up to Dec 11, 2026 Macrocyclic peptides are emerging as very potential candidates for drug development. Due to the advancement in display technologies, macrocycles can target undruggable proteins. These ... -
Proximity and Strain Driven Quantum Transport in Graphene
Graphene, with its relativistic band structure and high mobility, provides a promising ground for exploring emergent electronic phenomena when interfaced with other two-dimensional materials. By introducing symmetry-breaking ... -
Understanding the molecular mechanisms of redox-dependent mitochondrial homeostasis mediated by DJ-1 paralogs in Saccharomyces cerevisiae
Mitochondrial integrity is a crucial determinant of overall cellular health. Mitochondrial dysfunction and impediments in regulating organellar homeostasis contribute majorly to the pathophysiological manifestation of ... -
Spatio-temporal characteristics of precipitating clouds and rainfall over the Western Ghats of India
One of the heaviest rainfall receiving regions during the Indian summer monsoon season is anchored around the orographic barriers of the Western Ghats (WG) in peninsular India. The high rainfall is attributed to the forced ... -
Elucidation and prediction of ion transport in battery materials: A first-principles and machine learning study
Facile ionic mobility within host frameworks is crucial to the design of high-energy-density batteries with high-power-densities, where the activation energy required for ion migration (Em) between crystallographic sites ... -
Speech Based Low-Complexity Classification of Patients with Amyotrophic Lateral Sclerosis from Healthy Controls: Exploring the Role of Hypernasality
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder characterized by motor neuron degeneration, leading to muscle weakness, atrophy, and speech impairments. Dysarthria, an early symptom in approximately 30% ... -
Asymmetric Catalysis, Transition metal catalysis, Allylation, Propargylic alkylation, Cooperative catalysis and nonadjacent stereocenter
Transition metal catalysis has transformed asymmetric synthesis by enabling precise control of stereocenters, essential for bioactive molecules. This thesis outlines a systematic investigation of stereochemical complexity ... -
Scalable Solutions for Advancing the Performance and Reliability of 2D Transition Metal Dichalcogenides (TMDs)-Based Nanoelectronic Devices
The semiconductor device technology has evolved through the years by scaling down the device dimensions and changing device architecture to improve speed, power dissipation, packing density, and overall performance. To ... -
Design of viral entry inhibitors and vaccines
Full text Embargo upto 12/12/2026 Human Immunodeficiency Virus type 1 (HIV-1) remains one of the most persistent global health threats, despite significant efforts in the development of vaccines and major strides in ... -
Investigations on the total synthesis of oxasteroids
The thesis is divided into three parts: Part I: Review A review of the chemistry of known oxasteroids with particular emphasis on: Total synthesis Physiological activity Part II: Introduction Outlines the objectives ... -
Synthetic investigations on Azulenes
At present a variety of methods for the synthesis of azulenes are available. These can be divided under three main heads: I. Methods involving a change in ring size II. Methods by which a 7-membered ring is built on a ... -
studies in synthesis of 6-oxasteroids
Thesis Title Studies in: (I) Synthesis of 6-Oxasteroids and (II) Ultraviolet Spectra of 1,2-Dicyano Esters and Related Compounds The thesis is divided into three parts: Part I: Synthesis of 6-Oxasteroids Chapter I: A ... -
Investigations on the total synthesis of testorterone and its isomers : A thesis submitted to the I.I.Sc. for the degree of doctor of philosophy.
The thesis entitled "Investigations on the Total Synthesis of Testosterone and its Isomers" is divided into two parts. Part I consists of a comprehensive review of the earlier work done on the chemistry of testosterone and ... -
Synthetic studies in terpenes synthesis of the cis, trans-C-11 acid : The degradation product of agathic acid
The thesis entitled "Synthetic Studies in Terpenes – Synthesis of the cis/trans-C-11 Acid, the Degradation Product of Agathic Acid" is divided into two chapters. Chapter I is a comprehensive review of the chemistry of the ... -
Synthesis of fused heterocyclics
The thesis consists of two parts. Investigations on quinolinoquinolines are embodied in the first part, and investigations on (C3)quinazolones are embodied in the second part. Preceding the two parts, there is a brief ... -
Studies on the solid state decomposition of oxalic acid and ammonium oxalate Ph.D. Thesis
This thesis embodies studies on the photolysis of oxalic acid and ammonium oxalate and the low-temperature thermal decomposition of ammonium oxalate. From a detailed review of the literature, it was evident that very few ... -
Contributions to the chemistry of disulfur monoxide
Disulfur monoxide is an unstable gaseous species. Even at comparatively lower temperatures, it undergoes decomposition into sulfur dioxide and elemental sulfur. When dissolved in chilled carbon tetrachloride, the solution ...