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dc.contributor.advisorChatterjee, Kaushik
dc.contributor.authorRoy, Anindo
dc.date.accessioned2024-01-04T10:46:58Z
dc.date.available2024-01-04T10:46:58Z
dc.date.submitted2023
dc.identifier.urihttps://etd.iisc.ac.in/handle/2005/6365
dc.description.abstractBacterial colonization and biofilm formation on abiotic surfaces effectuate corrosion, fermentation, and infection resulting in tremendous economic and human losses each year. Aggravating the situation, new multi-drug resistant bacterial strains are emerging continuously, aided by the artificial selection of such strains due to antibiotic overuse, and spreading across the globe through living and non-living carriers. Deaths from drug-resistant microbial infections are rising while approvals of new antibiotic classes have been falling for more than a decade. Under such a scenario, the quest for alternative antibacterial strategies has gained the utmost importance. Nanomaterials such as metal nanoparticles, graphene, and more recently, bioinspired nanotopographies are among the most promising solutions to tackle this problem. Almost a decade ago, it was discovered that nanopillar topography of insect wings such as cicadas, dragonflies and damselflies can kill bacteria by physically rupturing their cell wall as the cells try to attach to the surface. This exciting discovery meant that if such topographies could be successfully emulated on surfaces of choice, the need for antibiotic administration could be eliminated and development of drug-resistant strains can be curtailed. This thesis focuses on engineering such bioinspired nanostructured surfaces to combat the spread of bacterial infections. The first part of the work in the thesis aims to replicate various high aspect ratio nanostructures on material surfaces, assess their bactericidal activity through experimental measurements and understand the various aspects of the mechanobactericidal phenomena. The second part of the thesis aims to develop technologies for affordable, and scalable adoption of these structures.en_US
dc.language.isoen_USen_US
dc.relation.ispartofseries;ET00377
dc.rightsI grant Indian Institute of Science the right to archive and to make available my thesis or dissertation in whole or in part in all forms of media, now hereafter known. I retain all proprietary rights, such as patent rights. I also retain the right to use in future works (such as articles or books) all or part of this thesis or dissertationen_US
dc.subjectcorrosionen_US
dc.subjectBacterial colonizationen_US
dc.subjectNanomaterialsen_US
dc.subjectGrapheneen_US
dc.subjectbioinspired nanotopographiesen_US
dc.subjectreactive ion etchingen_US
dc.subjectnanostructuresen_US
dc.subjectnanopillarsen_US
dc.subjecttitaniumen_US
dc.subject.classificationResearch Subject Categories::TECHNOLOGY::Engineering mechanicsen_US
dc.titleBioinspiration for battling bacteria: Nature inspired high aspect ratio nanostructures for new age antibacterial surfacesen_US
dc.typeThesisen_US
dc.degree.namePhDen_US
dc.degree.levelDoctoralen_US
dc.degree.grantorIndian Institute of Scienceen_US
dc.degree.disciplineEngineeringen_US


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