Browsing Physics (PHY) by Advisor "Ramakumar, S"
Now showing items 1-10 of 10
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Contributions To Venominformatics : Sequence-Structure-Function Studies Of Toxins From Marine Cone Snails. Application Of Order-Statistics Filters For Detecting Membrane-Spanning Helices
(2009-07-21)Venomous animals have evolved a vast array of peptide toxins for prey capture and defense. Nature has evolved the venoms into a huge library of active molecules with high selectivity and affinity, which could be explored ... -
Crystal Structure Analysis of a (B/a)8-TIM Barrel Enzyme and Its Mutants : Insights into the Role of Interactions Between Termini in Influencing Protein Stability. Experimental and Computational Study of Protein-Surface-Pockets Occluded by Tryptophan Side-Chains
Xylanases (EC 3.2.1.8) are glycosyl hydrolases that catalyze the hydrolysis of internal β-1,4 glycosidic bonds of xylan backbones, and have potential economical and environment friendly applications in the paper pulp, food, ... -
Crystal Structure Of Abrus Precatorius Agglutinin-I (APA-I) : Insights Into The Reduced Toxicity Of APA-I In Relation To Abrin. Formation Of Ordered Nanotubes Through Self Assembly In The Crystal Structures Of Dipeptides Containing α. β-dehydrophenylalanine
(2009-07-22)Ribosome Inactivating Proteins (RIPs) are protein or glycoprotein toxins that bring about the arrest of protein synthesis by directly interacting with and inactivating the ribosomes. Such toxins are in general, of plant ... -
Crystal Structure Of Mycobacterium Tuberculosis Histone Like Protein HU And Structure Based Design Of Molecules To Inhibit MtbHU-DNA Interaction : Leads For A New Target. Structure Aided Computational Analysis Of Metal Coordinated Complexes Containing Amino Acids And Organic Moieties Designed For Photo Induced DNA Cleavage
(2015-08-17)In bacteria, nucleoid associated proteins (NAPs) represent a prominent group of global regulators that perform the tasks of genome compaction, establishing chromosomal architecture and regulation of various DNA transactions ... -
Crystal Structures of Native and AdoMet Bound rRNA Methyltransferase from Sinorhizobium meliloti : Structural Insights into rRNA Recognition. Evolutionary, Structural and Functional Studies on Nucleoid-Associated Proteins HU and IHF
DNA- and RNA-binding proteins play a central role in gene regulation, which includes transcriptional control, alternative splicing, post-translational and transcriptional modifications like methylation and acetylation among ... -
Crystal Structures Of Native And Xylosaccharides-Bound Alkali Thermostable Xylanase From An Alkalophilic Bacillus SP. NG-27: Structural Insights Into Alkalophilicity. Analysis Of C-H...O Hydrogen Bonds In Helices Of Globular Proteins
(2007-11-21)Xylanases are xylan-degrading enzymes, belong to glycosyl hydrolases (GH). Xylanases from the two major families 10 (GH10) and 11 (GH11) catalyze the hydrolysis of internal β-, bonds of xylan backbone. Xylan is the second ... -
Crystal Structures of Sortase A from Streptococcus Penumoniae : Insights into Domain-Swapped Dimerization. Crystal Structures of Designed Peptides : Inhibitors of Human Islet Amyloid Polypeptide (hIAPP) Fibrillization Implicated in Type 2 Diabetes And Those Forming Self-Assembled Nanotubes
(2017-09-27)Sortases are cell-membrane associated cysteine transpeptidases that are essential for the assembly and covalent anchoring of certain surface proteins to the cell wall in Gram-positive bacteria. Thus, they play critical ... -
Implications in substrate recognition, catalysis and drug-design Structural basis for neutralization of ribosome-inactivating proteins by their monoclonal antibodies
Cryptic elements of proteins are not visible in unbound structures but become apparent in ligand/substrate-bound structures. These binary states of cryptic elements in protein structures can impact important aspects of ... -
Insights into Substrate Specificity in Sortase Enzymes from Structural Studies on a Novel Class of Housekeeping Sortase (SrtE) Identifying Functionally Important Cis-Peptide Containing Segments in Proteins and their utility in Molecular Function Annotation
(2018-02-21)Understanding protein function is fundamental to the fields of protein engineering and drug design. While most of the previous efforts in this direction have focused on the sequence-structure-function paradigm, recent ... -
De Novo Design Of Protein Secondary And Super Secondary Structural Elements: Investigation Of Interaction Patterns From The Crystal Structure Analysis Of Oligopeptides Containing α,β-Dehydrophenylalanine Crystal Structure Analysis Of Double Mutant M37L, P40S Thioredoxin From E.Coli
(2007-12-06)ΔPhe an analogue of a coded amino acid phenylalanine (Phe) residue but with double bond between Cα and Cβ atoms, is one of the well studied residue among all the dehydro amino acids, as a conformation constraining amino ...