Browsing Mathematics (MA) by Advisor "Chandra, Nagasuma"
Now showing items 1-6 of 6
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Computational Studies on Structures and Functions of Single and Multi-domain Proteins
(2018-05-25)Proteins are essential for the growth, survival and maintenance of the cell. Understanding the functional roles of proteins helps to decipher the working of macromolecular assemblies and cellular machinery of living ... -
A computational systems biology approach for elucidating molecular features of primary and metastatic melanoma
Malignant melanoma, a cancer arising from melanocytes, is reported to have one of the fastest growing incidence rates worldwide, and is considered to be one of the most aggressive human malignancies. According to the ... -
Graph Spectral Methods for Analysis of Protein Structures
Network representation of protein structures is an information-rich mode of examining protein structure, dynamics and its interactions with biomolecules. Graph spectral methods are extremely useful and powerful in analysing ... -
Multi-scale Modelling of HLA Diversity and Its Effect on Cytotoxic Immune Responses in Influenza H1N1 Infection
(2018-06-06)Cytotoxic T-lymphocytes (CTLs) are important components of the adaptive immune system and function by scanning the intracellular environment so as to detect and de-stroy infected cells. CTL responses play a major role in ... -
Structural Bioinformatics of Ligand Recognition in Proteins : A large-scale Analysis and Applications in Drug Discovery
Biological processes are governed by highly specific macromolecular interactions. Understanding the precise mechanism of ligand recognition in proteins is essential for deriving features responsible for such recognition ... -
Studies on Dynamic Plasticity of Ligand Binding Sites in Proteins
Molecular recognition between proteins and their associated ligands constitutes ligand-induced protein rewiring thereby enabling the formation of a stable protein-ligand complex. The studies presented in this thesis address ...