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Design Principles of Phenotypic Robustness and Plasticity in Gene Regulatory Networks underlying Cancer Metastasis
Metastasis – the process of cancer cells leaving the primary tumor and colonizing multiple organs – remains a major cause of cancer mortality. However, it is a highly inefficient process with only 0.01% of disseminated ...
Multistability in cellular differentiation enabled by three and four node mutually repressive regulatory networks: A case study of CD4+ T-cell decision making
Cellular differentiation is controlled by the complex dynamics of gene regulatory networks (GRNs), often featuring multistability, where multiple stable states represent different phenotypes. A common example is the toggle ...
Stable Isotope and Geochemical Approaches for Hydrological Characterization and Estimation of Seasonal Groundwater Inputs in the Humid to Semi-Arid Reach of the Kabini River, South India
In tropical catchments, like the Kabini region of South India, understanding the intricate contributions of baseflow is essential for sustainable water management and ecosystem preservation. Baseflow, which is predominantly ...
Diabetogenesis and Albumin Molecular Modifications Newer Biological Insights and Clinical Implications
To address the many unmet scientific needs in diabetes care (pathogenesis pathways, earliest diagnosis, efficient monitoring, safer and better therapies and importantly prevention approaches), our research focussed on: (a) ...
Architectures for linewidth reduction in cascaded Raman fiber lasers and applications
Fiber lasers have been increasingly used as a high-power source due to several advantages, such as superior beam quality, better thermal management, high efficiency, and compact and reliable design. In fiber lasers, ...
An Investigation of the Characteristics of Monsoon Low Pressure Systems in the Present Climate and their Sensitivity to Topography and Climate Change
Monsoon Low-Pressure Systems (LPS) are synoptic-scale tropical disturbances that periodically form over the Indian subcontinent during the summer monsoon season (June-September). Apart from being a lifeline to agriculture, ...
Droplet, Jets, and Leaky Surfaces
Surface structuring on a micro-nano scale, combined with a low surface energy coating, leads to anti-wetting properties. Such surfaces also exhibit other properties such as self-cleaning, antifouling, bacteriostatic, drag ...
Molecular determinants of self-assembly of the pore forming toxin Cytolysin A
Pore forming toxins (PFTs) belong to a class of bacterial exotoxins that disrupt the
biological membrane barrier by formation of nanopores. These toxins are central to
the virulence of pathogens such as S. pneumoniae, ...
Insights into signalling and crosstalk in two-component signalling systems of Mycobacterium tuberculosis
Tuberculosis (TB), caused by the pathogen Mycobacterium tuberculosis (Mtb), has very recently reclaimed the position of the leading cause of deaths in humans from a single infection agent. This suggests a dire need to ...
Effect of Single Residue Change on Conformational Dynamics of Proteins and Their Function: A Molecular Dynamics Study
Proteins undergo conformational transitions and exhibit specific motion while performing their function. A single residue change (addition, deletion, or substitution) can sometimes influence the protein dynamics and disrupt ...