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Study of Enantiomeric Discrimination and Enzyme Kinetics using NMR Spectroscopy
(2018-04-06)
Obtaining enantio pure drug molecules is a long standing challenge in asymmetric synthesis implying that the identification of enantiomers and the determination of enantiomeric purity from a racemic mixture are of profound ...
Phase Transition In Soft-Condensed Matter Fluids And Contribution To Enzyme Kinetics Including Kinetic Proofreading
(2016-11-16)
The thesis involves computer simulation and theoretical studies of phase transition in soft-condensed matter systems and theoretical understanding of enzyme kinetics along with kinetic proofreading of tRNA-aminoacylation ...
Electrochemical Detection Of Proteins : Myoglobin As A Case Study
(2015-09-08)
An effective electrochemical sensor for myoglobin (Myb) detection was developed using a simple procedure of denaturing the protein with guanidine hydrochloride and detecting the released heme group by cyclic voltammetry. ...
Study Of Structure, Dynamics & Self-Assembly Of Human Insulin-Like Growth Factor Binding Protein-2 By Novel NMR And Biophysical Methods
(2014-08-05)
My research work for PhD has focused on: (i) the development and application of new NMR methodologies to solve challenging problems in structural biology and (ii) studying important biological systems to correlate their ...
Chemistry Of Ferrocene Conjugates Showing DNA Cleavage And Photocytotoxic Activity
(2013-06-26)
Ferrocene is an important molecule in the field of chemical biology due to its stability, unique redox property and significant lipophilicity for better cellular delivery. The medicinal importance of ferrocene is well ...
Design And Access To Disallowed And Unusual Conformers Of Peptides In Crystals And In Solution : Structural Consequences Of The Imidate And Thioimidate Isosteres For The Peptide Bond
(2016-03-04)
This thesis entitled “Design and Access to Disallowed and Unusual Conformers of Peptides in Crystals and in Solution: Structural Consequences of the Imidate and Thioimidate Isosteres for the Peptide bond” is divided into ...
Synthesis, Structural and Biophysical Studies of Oligosaccharide Glycolipids and Glycosidic Bond Expanded Cyclic Oligosaccharides
(2018-02-15)
Pathogenesis originating from mycobacterial invasion on host cells is prevalent and is a major challenge in efforts towards overcoming the burden of mycobacterial diseases. Complex architecture of mycobacterium cell wall ...
Synthesis of Glycosyl Amino Acids, Glyco Amino Acids & α-Amino γ-Lactams from Carbohydrate Derived Donor-Acceptor Cyclopropanes
(2017-11-22)
Synopsis
The thesis entitled “Synthesis of Glyco-amino-acids, Glycosyl-amino-acids, and α-Amino γ-Lactams from Carbohydrate Derived Donor-Acceptor Cyclopropanes” is divided into five chapters.
Chapter 1: Introduction ...

