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Extending Aryne Chemistry: Application to Insertion Reactions, Multicomponent Couplings, Molecular Rearrangements and Arylation Reactions
Arynes are highly reactive electrophilic intermediates, which can be utilized in various carbon-carbon bond-forming reactions including pericyclic reactions, insertion reactions,
multicomponent couplings (MCCs), molecular ...
Total synthesis of the macrolactone core of migrastatin, formal synthesis of (+)-ratjadone A, and towards the synthesis of sphingofungin F
The thesis entitled “Total synthesis of the macrolactone core of migrastatin, formal synthesis of (+)-ratjadone and Towards the total synthesis ofsphingofungin F” is divided into three chapters and an appendix highlighting ...
Achieving Efficiency and Specificity in Multifarious Systems for Anti-cancer Gene Therapeutics
The research work described in this thesis encompasses the syntheses, characterization and bioactivity determination of various novel systems crafted for achieving high efficacy and targeted gene therapeutic effect in ...
Nucleophilic Addition reactions of 2-Aza-allyl anion: Application to the Total Synthesis of Natural Products
The thesis entitled “Nucleophilic Addition reactions of 2-Aza-allyl anion: Application to
the Total Synthesis of Natural Products’’ is divided into two sections with an appendix.
First section of the thesis details the ...
Design and Synthesis of Stimuli-responsive Gelators and Novel Gemini Surfactants and Characterization of their Properties upon Self-assembly
Chapter 1. A Brief Overview of Gemini Surfactants and Low Molecular-Weight Gelators (LMWGs)
The first part of this chapter gives a brief account of the research done in the area of aqueous 3D-(ca. micelles and vesicles ...
Development of Stimuli-Responsive Self-Assembled Materials for Biomolecular Applications
The thesis entitled ‘‘Development of Stimuli-Responsive Self-Assembled Materials for Biomolecular Applications’’ deals with the design, synthesis, and characterisation of low molecular weight hydrogel systems as well as ...
Catalytic Enantioselective Allylic Alkylative Desymmetrization, Carbon-Carbon and Carbon-Heteroatom Bond Forming Reactions
In summary, we have developed a catalytic enantioselective desymmetrization of prochiral
1,3-dinitropropanes, which proceeds via enantiogroup differentiating allylic alkylation
reaction. Functionalized allylic carbonates ...
Synthetic Applications of C-2 Substituted Glucal
This report concerns the development of a synthetic approach towards synthesis of seven-membered septanosides, such as, substituted oxepanes from protected 2-hydroxyglycals. Important precursors to the synthesis of the ...
Ru (II)-Catalyzed C−H Activation: Amide-Directed 1,4-Addition of Ortho C−H Bond to Maleimides
Transition metal catalyzed functionalization of C-H bond to C-C bond is advantageous and
atom economical. The use of directing groups is intended to overcome the challenges associated
with the C-H activation such as low ...
Engaging Small Organic Molecules and Self-Assemblies for ‘Label-Free’ Recognition of Biologically Relevant Analytes
The thesis entitled ‘Engaging Small Organic Molecules and Self-Assemblies for
‘Label-Free’ Recognition of Biologically Relevant Analytes’ mainly deals with design and
synthesis of various types of small molecular probes ...