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Synthesis of Amyloidogenic Peptides and Endosomolytic Peptides for Functional and Intracellular Protein Delivery Studies.
Over the past few decades, peptide research gained lot of prominence due to their extensive usage in and across domains ranging from biomedical to bio-material science. This thesis deals with two different types of peptides ...
Theoretical Studies of Polymer Dynamics in Confined Spaces
The growing use of micro- and nano-fabricated devices to study complex biological processes has made it increasingly important to understand the effects of confinement on macromolecular behaviour. In this thesis, I will ...
Shock Tube Investigation and Modeling of Dicyclopentadiene: Fundamental to Application
Dicyclopentadiene (DCPD), a homodimer of cyclopentadiene (C5H6) was chosen for the present study. DCPD can be obtained by dehydrogenation of JP-10 (jet propellant C10H16) which is currently used as aviation fuel. The ...
Theoretical investigation of H atom tunneling in Catecholate Monoanion: A combined time-independent and time-dependent quantum mechanical study
This thesis presents a combined time-independent and time-dependent quantum mechanical
study of a system, Catecholate Monoanion (CM) for the study of H atom tunneling. It has an
intramolecular H bond leading to a symmetric ...
Investigation of Psychrophilic SUMO Proteases: Towards a More Efficient SUMO Protease at Lower Temperature
Covalent attachment of the fusion protein, Small Ubiquitin-like modifier (SUMO), to recalcitrant
target proteins (especially transmembrane proteins) make purification of the target protein much
easier by enhancing its ...
Polymerizable Porogen – Direct generation of internally functionalized porous polymers
Bicontinuous functional porous polymers are desirable in terms of pore accessibility, particularly for applications in templating, chromatographic separation, and catalysis. Bicontinuous morphologies can be obtained by ...
Dynamics of Quantum Supercooled Liquids: A Mode Coupling Approach
In this thesis, I use the quantum mode coupling theory (QMCT) formulation to
study the dynamics in a supercooled liquid to understand how quantum fluctuations affect the liquid-glass transition. I calculate the Kubo-transformed ...
Studies on BODIPY Appended Ruthenium(II) Complexes for Bioimaging and Photodynamic Therapy Applications
Photodynamic therapy (PDT) is a medical technique that utilizes light, oxygen, and a photosensitizer to treat several medical conditions, including cancer. Because of the limitations and side effects of traditional anticancer ...
Design, Synthesis and Optical Characterization of 1,8-Naphthalimide based D-pi-A System
Design, Synthesis and Optical Characterization of 1,8-Naphthalimide based D-pi-A System
Luminescent materials find a lot of application in the field of OLEDs and bio-medical applications [1-2]. Our group has recently ...
Analytical models of selected stochastic processes in condensed phase systems
This thesis is a record of the research I have carried out over the last five years to understand a selection of problems in the broad area of single-molecule physics. These problems cover four broad themes: (i) dynamically ...