Division of Biological Sciences: Recent submissions
Now showing items 501-520 of 1093
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Physiological Interactions between Neuronal Active Conductances And Inositol Trisphosphate Receptors in Neurons and Astrocytes
(2018-07-23)Intricate interactions among constituent components are defining hallmarks of biological systems and sculpt physiology across different scales spanning gene networks to behavioural repertoires. Whereas interactions among ... -
Enterovirus Non-structural Protein 3A Interactions with Sec12, an upstream Component of the COPII Secretory Pathway and Implications for Viral Replication
(2018-07-20)Polioviruses, Coxsackieviruses, and Echoviruses belonging to the Picornaviridae family of positive-stranded, non-enveloped viruses, are highly infectious and associated with a range of illnesses in children from minor ... -
In Silico Perspectives on RNA Structures Modulating Viral Gene Expression and Mechanics of tRNA Transport
(2018-07-19)The repertoire of cellular functions mediated by Ribonucleic acid (RNA) molecules have expanded considerably during the last two decades. The role played by RNA in controlling and regulating gene expression in ... -
Design and Stabilization of Stem Derived Immunogens from HA of Influenza A Viruses
(2018-07-19)Influenza virus belongs to the Orthomyxovirus family of viruses that causes respiratory infection in humans, leading to morbidity and mortality. The mature influenza A virion has an envelope that contains two major surface ... -
Role of AMP-Activated Protein Kinase in Cancer Cell Survival under Matrix-Deprived Conditions
(2018-07-19)Cancer progression is a multi-step process requiring cells to acquire specific properties that aid the neoplastic growth. One such property is the ability to survive in the absence of matrix-attachment, a critical necessity ... -
Host-Pathogen Interactions in Hepatitis C Virus Infection : Deciphering the Role of Host Proteins and MicroRNAs
(2018-07-19)Host-pathogen interactions in Hepatitis C Virus infection: Deciphering the role of host proteins and microRNAs Hepatitis C virus (HCV) is a positive sense single stranded RNA virus belonging to the Hepacivirus genus of ... -
Arabidopsis Serine/Threonine/Tyrosine Protein Kinase : Implications in Growth And DEvelopment
(2018-07-19)Protein phosphorylation is a key cellular regulatory mechanism. Phosphorylation can either activate or inhibit the function of a particular protein. Activation of protein kinases has been implicated in response to light, ... -
Mechanisms of Dopaminergic Neurodegeneration in Parkinson's Disease
(2018-07-18)Parkinson’s disease (PD) is a debilitating movement disorder. The cardinal symptoms of PD are bradykinesia, resting tremors and rigidity. PD is characterized by degeneration of dopaminergic neurons of A9 region, substantia ... -
Secondary Structures in Proteins : Identification and Analyses
(2018-07-12)Proteins are large biomolecules consisting of one or more long chains of amino acid residues. They perform a vast array of functions within living organisms. In this thesis, we present analyses of different secondary ... -
Development of a Selective Cell-Permeable Protein Phosphatase 1 Inhibitor
(2018-07-10)Selective ‘super-specific’ inhibitors of Protein Phosphatase 1 (PP1) are not available. Several natural product toxins possessing marginal selectivity between PP1 and the closely related Protein Serine/Threonine Phosphatase ... -
Investigating the Impact of Habitat Disturbance and the Role of Functional Traits in a Tropical Butterfly Assemblage
(2018-07-09)Tropical habitats face a diverse range of anthropogenic threats. Two common and important threats to tropical biodiversity are invasive species and roads. Invasive plants are proposed to be a major threat to biodiversity ... -
Game of Thrones : Direct Fitness through Nest Foundation in the Primitively Eusocial Wasp Ropalidia Marginata
(2018-07-09)Reproduction is the avenue for gaining direct fitness. But in certain species some individuals do not reproduce, instead gain indirect fitness by helping relatives to reproduce; the prime examples for this come from the ... -
Stress Physiology of Free-ranging Asian Elephants (Elephas maximus) : Influence of Ecological and Anthropogenic Stressors
(2018-07-09)Various ecological and human-induced disturbances play an important role in defining the health of an animal. To cope up with such threats or challenges to its homeostasis, an animal responds by secreting stress hormones ... -
Urbanisation and Shifting Phenotypes Behavioural, Physiological and Cognitive Strategies of the Indian Rock Agama Psammophilus Dorsalis
(2018-07-09)Humans directly or indirectly cause changes in the environment, and urbanisation is currently one of the most important threats to biodiversity. Urbanisation exposes organisms to novel pressures that are drastically different ... -
Solution Structure Studies on the Effects of Aromatic Interactions and Cross-Strand Disulfide Bonds on Protein Folding
(2018-07-05)The work presented in this thesis focusses primarily on the determination of protein structure at atomic resolution, with NMR spectroscopy as the principle investigative tool. The thesis is divided into four parts. Part I ... -
For Queen and Country : Reproductive and Non-Reproductive Division of Labour in the Primitively Eusocial Wasp Ropalidia Cyathiformis
(2018-07-05)Division of labour is a hallmark of eusocial insects and is believed to be a major factor in their evolutionary success and ecological dominance. Division of labour can be of two kinds – reproductive division of labour ... -
Structural and Functional Studies on Pyridoxal Kinase and Pyridoxal 5′-phosphate Dependent Enzymes
(2018-07-04)Most of the chemical reactions of living cells are catalyzed by protein enzymes. These enzymes are very efficient and display a high degree of specificity with respect to the reaction catalyzed. Cellular activities depend ... -
Molecular Insights into Lymphoid Malignancy : Role of Transcription Factor BCL11B in T-cell Leukemia Genesis and Biochemical Characterization of DNA Binding Domain of RAG1
(2018-06-29)The lymphoid tissues consist of distinct cell subpopulations of B and T cell lineages and possess complex signaling pathways that are controlled by a myriad of molecular interactions. During the fine-tuned developmental ... -
Understanding Patterns of Bird Species Distribution in the Western Ghats
(2018-06-23)Macroecology is the study of relationships between organisms and the environment at large spatial and temporal scales. This field of research examines patterns in species abundance, distribution and diversity. Understanding ... -
Role of the ELONGATED GYNOPHORE/ELONGATA2 Protein in Fruit and Root Development in Arabidopsis Thaliana
(2018-06-23)In order to identify new players in fruit development, a forward genetic screen was performed on EMS mutagenized plants. A mutant named elongated gynophore (egy) was identified in the M2 population based on altered fruit ...