Division of Biological Sciences: Recent submissions
Now showing items 441-460 of 1085
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Anti-thrombotic Secondary Metabolites from Endophytic Fungi of Datura Metel and Cassia Fistula
Blood coagulation is a process that occurs normally in an animal during bleeding, to prevent the loss of blood from the body and is assisted by two key players -blood platelets and coagulation factors particularly thrombin. ... -
Computational and Experimental Approaches to Protein Design
Protein design is a rapidly maturing field, with the goal of designing proteins with customized structures and functions. A large number of protein structures are experimentally determined, which have facilitated an ... -
Understanding the Sequence Dependence of NHEJ Mediated Double-strand Break Repair, and Identification of Novel DNA Ligase Inhibitors and their Potential Use as Cancer Therapeutics
Repair of DNA breaks is essential for maintenance of genomic integrity. DNA double-strand breaks (DSBs) are considered as the most harmful DNA lesions within the cells which if left unrepaired or are misrepaired, can lead ... -
Theta-band Spectral Selectivity and Gamma-range Coincidence Detection in Spike Initiation Dynamics of Hippocampal Pyramidal Neurons
In the pursuit to understand information processing in the brain, a general question that is often posed is: What is the neuron encoding? This is addressed by assessing feature selectivity in sensory neurons, which informs ... -
Isolation, Structure Elucidation and Functional Characterization of a Novel Cytotoxic Secondary Metabolite Phomafuranone, 2-Hydroxy-2, 4-dimethyl-5-[-1-propen-1-yl]-3(2H)-furanone, from Phoma tropica an Endophytic Fungus Isolated from Mappia foetida.
Cancer has become the leading disease-related cause of death in the human population. For example, in the United States, cancer is the second leading cause of death behind cardiovascular disease, and it is projected that ... -
Understanding the Biology of Heat Shock Protein 90 in Opportunistic Fungal Pathogens
Heat shock protein 90 is one of the most abundant and evolutionary conserved class of molecular chaperones present throughout the biological kingdom. It is a specialist chaperone as its function extends beyond protein ... -
Deciphering Functions & Interactions of Fission Yeast Splicing Factor SpSlu7 Relevant to Constitutive & Alternative Splicing
The fission yeast genome with abundant multi-intronic transcripts, degenerate splice signals and presence of alternative splicing machinery is an attractive unicellular fungal model to investigate splice-site recognition ... -
Alternate Fates of tRNAs in Initiation and Elongation
Protein synthesis in all organisms utilizes a special tRNA called the initiator tRNA. Initiator tRNAs take part in the initiation step of protein synthesis by their direct binding to the P‐site of the ribosome. The other ... -
(p)ppGpp and c-di-GMP : A Tale of Two Second Messengers in Mycobacterium smegmatis
Nucleotide based second messengers are known to regulate wide variety of processes in all domains of life. Two such bacterial second messengers are (p)ppGpp (guanosine tetra- or pentaphosphate) and c-di-GMP (cyclic dimeric ... -
Genetics of Drosophila Indirect Flight Muscles : Unraveling the Roles of Genes Involved in Muscle Development and Function
Myofibrillogenesis is a complex process involving assembly of many structural proteins in an orchestrated spatio-temporal manner to form a highly ordered contractile sarcomeric unit. Mutations in the proteins involved in ... -
Spatial and Coevolutionary Dynamics of Cooperation
Cooperation is ubiquitous across taxa in the animal kingdom. For example, microbes cooperate in producing antibiotic-resistant biofilms, mammals and birds collectively mob predators, and humans cooperate in utilization of ... -
On Trait Evolution in a Heterogeneous Environment: Oviposition Site Selection in a Mosquito in Response to Multiple Risk Factors
A focus in evolutionary biology is to understand the drivers of diversity in animal behavioural traits in the living world. Animals facing similar problems in the environment, such as the problem of how much to invest in ... -
HIV-1 Immunogen Design : Envelope Protein Minimization, Stabilization and Glycan Removal
Effective vaccines exist for a number of viral diseases. However, despite much effort, there is no successful vaccine against the Human Immunodeficiency Virus (HIV-1). The envelope glycoprotein (Env) of HIV-1 gp120, the ... -
Carbon Starvation Genes Mediate the Cross-talk Between Metabolism and Pathogenesis of Salmonella Typhimurium
Carbon starvation genes mediate the cross-talk between metabolism and pathogenesis of Salmonella Typhimurium Salmonella enterica serovar Typhimurium (S. Typhimurium) can infect a wide range of host animals to cause diseases ... -
Rational Elicitation of Cold Sensitive Phenotypes
Conditional gene expression and conditional mutants provide a means to modulate the expression of specific genes and to control the activity of their protein products in vivo, so as to be able to study their effects on the ... -
Exploring the Unusual Properties and Non-canonical Roles of Promiscuous Restriction Endonuclease KpnI
Restriction modification (RM) systems are important components of bacterial immune system. Their primary function is to protect the bacteria from invading bacteriophages. Based on the subunit composition, enzyme properties ... -
Plasticity of Intrinsic Excitability in Fast Spiking Interneurons of the Dentate Gyrus & Its Implications for Neuronal Network Dynamics
Inhibitory GABAergic neurons, although forming a minor proportion of the neuronal population in the central nervous system, have been reported to be crucial for different physiological states of the brain. Among the vast ... -
Neural Mechanisms underlying the planning of sequential saccades
Saccades are rapid eye movements that we continually make (about 2-3 times per second) to look around and scan our visual environment. Though we effortlessly execute saccadic eye movements all the time, they are not just ... -
Exploring the Roles of Phase Variable HpyAII Restriction-modification System in the Human Pathogen Helicobacter pylori
Helicobacter pylori is a Gram-negative microaerophilic bacteria known to infect as much as 80% of some populations with an average morbidity range of around 50% of the world population. It has been recognized as a definitive ... -
Functional Insights into the Canonical and Non-canonical Roles of the Fission Yeast Splicing Factor SpPrp16
The spliceosome is a large multi-megadalton RNA-protein machine which facilitates the removal of introns from eukaryotic nascent pre-mRNAs by two concerted transesterification reactions. The spliceosome is comprised of ...