Division of Biological Sciences: Recent submissions
Now showing items 381-400 of 1031
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Cellular and Molecular Features of the Response of Mycobacterium smegmatis to Rifampicin and Moxifloxacin Upon Prolonged Exposure
Bacterial persisters are a subpopulation of bacteria that can tolerate lethal concentrations of antibiotics. These are phenotypic variants that can give rise to drug‐susceptible population upon withdrawal of the antibiotic. ... -
Rotavirus Viroplasm Structure (VS) : The First Insights into the Architectural Assembly of the Viral and Host Factors in the VS"
Rotavirus is a major cause of acute gastroenteritis in infants and young children and responsible for approximately 453,000 infantile deaths per year. Rotaviruses are non-enveloped RNA viruses belonging to the Reoviridae ... -
Deciphering the Role of METTL3-Dependent m6A-epitranscriptome in Glioma Stem-like Cells
The major roadblocks in treatment for GBM are resistance to therapy and recurrence of GBM cells. Regardless of various treatment strategies, the average survival of GBM patients is poor and incidence of recurrence remains ... -
G-Protein Coupled Estrogen Receptor (hGPER)- Mediated Action of 17β-Estradiol on hTREK-1 Potassium Channel
TREK-1 is a two-pore domain potassium channel that contributes to maintenance of the resting membrane potential of a cell. TREK-1 is involved in several physiological and pathophysiological conditions like nociception, ... -
Targeting RAD51C Pathological Mutants by Synthetic Lethality and Extended Functions of RAD51C/XRCC3 in Mitochondrial Genome Maintenance
To counteract the potentially calamitous effects of genomic instability in the form of double-strand breaks (DSBs), cells have evolved with two major mechanisms. First, DNA non¬homologous end joining (NHEJ) which requires ... -
Structure and Dynamics of a Tropical Dry Forest Plant Community
This thesis is spurred by the overarching question “why is a plant where it is in space and time?”, which, when asked in different global communities over the last century or so, has contributed to the development of general ... -
Anti-thrombotic Secondary Metabolites from Endophytic Fungi of Datura Metel and Cassia Fistula
Blood coagulation is a process that occurs normally in an animal during bleeding, to prevent the loss of blood from the body and is assisted by two key players -blood platelets and coagulation factors particularly thrombin. ... -
Computational and Experimental Approaches to Protein Design
Protein design is a rapidly maturing field, with the goal of designing proteins with customized structures and functions. A large number of protein structures are experimentally determined, which have facilitated an ... -
Understanding the Sequence Dependence of NHEJ Mediated Double-strand Break Repair, and Identification of Novel DNA Ligase Inhibitors and their Potential Use as Cancer Therapeutics
Repair of DNA breaks is essential for maintenance of genomic integrity. DNA double-strand breaks (DSBs) are considered as the most harmful DNA lesions within the cells which if left unrepaired or are misrepaired, can lead ... -
Theta-band Spectral Selectivity and Gamma-range Coincidence Detection in Spike Initiation Dynamics of Hippocampal Pyramidal Neurons
In the pursuit to understand information processing in the brain, a general question that is often posed is: What is the neuron encoding? This is addressed by assessing feature selectivity in sensory neurons, which informs ... -
Isolation, Structure Elucidation and Functional Characterization of a Novel Cytotoxic Secondary Metabolite Phomafuranone, 2-Hydroxy-2, 4-dimethyl-5-[-1-propen-1-yl]-3(2H)-furanone, from Phoma tropica an Endophytic Fungus Isolated from Mappia foetida.
Cancer has become the leading disease-related cause of death in the human population. For example, in the United States, cancer is the second leading cause of death behind cardiovascular disease, and it is projected that ... -
Understanding the Biology of Heat Shock Protein 90 in Opportunistic Fungal Pathogens
Heat shock protein 90 is one of the most abundant and evolutionary conserved class of molecular chaperones present throughout the biological kingdom. It is a specialist chaperone as its function extends beyond protein ... -
Deciphering Functions & Interactions of Fission Yeast Splicing Factor SpSlu7 Relevant to Constitutive & Alternative Splicing
The fission yeast genome with abundant multi-intronic transcripts, degenerate splice signals and presence of alternative splicing machinery is an attractive unicellular fungal model to investigate splice-site recognition ... -
Alternate Fates of tRNAs in Initiation and Elongation
Protein synthesis in all organisms utilizes a special tRNA called the initiator tRNA. Initiator tRNAs take part in the initiation step of protein synthesis by their direct binding to the P‐site of the ribosome. The other ... -
(p)ppGpp and c-di-GMP : A Tale of Two Second Messengers in Mycobacterium smegmatis
Nucleotide based second messengers are known to regulate wide variety of processes in all domains of life. Two such bacterial second messengers are (p)ppGpp (guanosine tetra- or pentaphosphate) and c-di-GMP (cyclic dimeric ... -
Genetics of Drosophila Indirect Flight Muscles : Unraveling the Roles of Genes Involved in Muscle Development and Function
Myofibrillogenesis is a complex process involving assembly of many structural proteins in an orchestrated spatio-temporal manner to form a highly ordered contractile sarcomeric unit. Mutations in the proteins involved in ... -
Spatial and Coevolutionary Dynamics of Cooperation
Cooperation is ubiquitous across taxa in the animal kingdom. For example, microbes cooperate in producing antibiotic-resistant biofilms, mammals and birds collectively mob predators, and humans cooperate in utilization of ... -
On Trait Evolution in a Heterogeneous Environment: Oviposition Site Selection in a Mosquito in Response to Multiple Risk Factors
A focus in evolutionary biology is to understand the drivers of diversity in animal behavioural traits in the living world. Animals facing similar problems in the environment, such as the problem of how much to invest in ... -
HIV-1 Immunogen Design : Envelope Protein Minimization, Stabilization and Glycan Removal
Effective vaccines exist for a number of viral diseases. However, despite much effort, there is no successful vaccine against the Human Immunodeficiency Virus (HIV-1). The envelope glycoprotein (Env) of HIV-1 gp120, the ... -
Carbon Starvation Genes Mediate the Cross-talk Between Metabolism and Pathogenesis of Salmonella Typhimurium
Carbon starvation genes mediate the cross-talk between metabolism and pathogenesis of Salmonella Typhimurium Salmonella enterica serovar Typhimurium (S. Typhimurium) can infect a wide range of host animals to cause diseases ...