Division of Biological Sciences: Recent submissions
Now showing items 321-340 of 1085
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Structural and mechanistic studies on Staphylococcal RNA degrading enzymes and multienzyme complexes
RNA degrading enzymes and multi-enzyme complexes govern a variety of cellular processes. The role of these enzymes and multi-enzyme assemblies has been suggested to govern gene expression levels in bacteria with modulations ... -
Towards precision medicine to detect, characterize and treat liver cancer: Large-scale data analyses using genome-wide networks
In summary, various systems biology approaches were applied to identify a potential genesignature set to monitor CLD progression which can help in the early detection of HCC. An unbiased analysis of metabolic alterations ... -
Structural and functional studies on DNA damage inducible protein 1 (Ddi1) from protozoa
Structural and functional investigations on DNA-damage inducible protein1 (Ddi1) from Entamoeba histolytica, Trypanosoma cruzi and Toxoplasma gondii have been carried out. Ddi1 belongs to the ubiquitin receptor family of ... -
Computational Investigation of Heterogeneous Lateral Organisation in Biological Membrane
The study of lateral heterogeneity on membrane surface has come a long way from the fluid mosaic model. Simulations and experimental studies have observed non-random mixing of lipids and proteins in the membrane. In this ... -
SRF regulates the generation of neuroprotective astrocytes in the brain
In response to injuries, infections or in neurodegenerative disorders, astrocytes get activated to become reactive. This phenomenon is called astrogliosis and is marked by a spectrum of changes which encompasses structural, ... -
The influence of landscape composition on butterfly populations: A behavioural ecological approach
Overall, taking behavioural ecological and trait-based approaches, my study suggests that the distribution of a species and patterns in its population densities in a landscape are affected by diverse ecological variables, ... -
Structural Studies on the Intracellular Steps that Govern the Staphylococcus aureus Quorum Sensing System.
Quorum sensing in bacteria has been extensively examined over the past two decades. These studies suggest that the molecular mechanism that governs quorum sensing incorporates niche-specific, environmentally sensitive ... -
Spatio-temporal Regulation of GPCR mediated MAPK Transactivation in Living Cells
Signal transduction is a mode of cellular communication essential for an organism’s sustenance and survival. Cell communication in higher organisms is largely executed by two classes of cell surface receptors i.e. G-protein ... -
Proteomics-based Identification of Serum Biomarkers : Role of Secreted MCSF and CRP in Glioma Pathogenesis
Gliomas are the neoplasia of glial cells present in the brain and comprises of more than 70% of all the neoplasms of the central nervous system. They consist of a family of primary brain tumors that are categorized based ... -
Deciphering the genetic regulators of cuticle barrier function and longevity in Caenorhabditis elegans
Ever since Sydney Brenner introduced Caenorhabditis elegans in the early 60s as a model system, this worm has contributed to many ground-breaking discoveries in science. It has served as an excellent model to study animal ... -
Patterns and Drivers of Multimodal Signalling in Diurnal Geckos
Effective communication in animals comprise emission of a signal by a signaller and a response by a receiver, such that the interaction is beneficial to either only the signaller, or both the signaller and the receiver. ... -
Identifying key determinants underlying variable efficacy of BCG substrains against Pulmonary TB.
Protection conferred by BCG vaccine against adult pulmonary TB ranges from 0–80% based on large, well-controlled field trials. This variability is highly significant (P < 0.0001) and is regarded as being indicative of true ... -
Crystallographic and analytical ultracentrifugation studies of the E. coli acetohydroxy acid synthase I enzyme
This thesis ellucidates the mechanism of activation and regulation of AHAS I enzyme from Escherichia coli that was characterised using crystallographic and sedimentation velocity analytical ultracentrifugation studies. AHAS ... -
Characterization of mouse Apolipoprotein L9 and investigation of its cellular functions
This thesis is divided into 3 chapters. Chapter 1, titled General Introduction, is a chapter that familiarizes the reader with the general subject matter of the thesis so that the content of Chapters 2 and 3 can ... -
Small Heat Shock Proteins from Bacteria and a Bacteriophage
Proteins can unfold during heat and other types of stress and tend to aggregate with subsequent loss of function. This event is prevented by small Heat Shock Proteins (sHSPs) acting as molecular chaperones. sHSPs do not ... -
The Molecular Basis for the Differential Antibiotic Susceptibility of Mycobacterial Subpopulations
Mycobacterial populations have evolved various strategies to withstand diverse stress conditions in the environment. One among these strategies is maintenance of phenotypic heterogeneity, in terms of cell morphology, ... -
Functional Characterization of CG9650 in development of the Indirect Flight Muscles of Drosophila melanogaster
Muscle development is a complex and multifactorial process involving assembly of thousands of proteins in a precise and synchronized manner over the course of development of an organism. Multiple genes and signalling ... -
Understanding the Mechanism of Double-strand Break Repair and Genome Fragility in Mammalian Mitochondria
Mitochondria are semiautonomous organelles in a cell as they have their own genome that replicates independently. It plays a major role in oxidative phosphorylation due to which mitochondrial DNA (mtDNA) is frequently ... -
Scanning mutagenesis studies of HIV-1 Env immunogenicity and structure
Human Immunodeficiency Virus type 1 (HIV-1) is the etiological agent of Acquired Immunodeficiency Syndrome (AIDS). AIDS is a global pandemic with 36.7 million people living with HIV-1 all over the world and approximately ... -
Design, Synthesis, and Bioactivity of Thioamidated Macrocyclic Peptides
The work presented in this thesis describes the comprehensive study related to thioamidated macrocyclic peptides. We study the underexplored class of peptide bond isostere; thioamides in the context of small macrocyclic ...