Division of Biological Sciences: Recent submissions
Now showing items 281-300 of 1030
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The Molecular Basis for the Differential Antibiotic Susceptibility of Mycobacterial Subpopulations
Mycobacterial populations have evolved various strategies to withstand diverse stress conditions in the environment. One among these strategies is maintenance of phenotypic heterogeneity, in terms of cell morphology, ... -
Functional Characterization of CG9650 in development of the Indirect Flight Muscles of Drosophila melanogaster
Muscle development is a complex and multifactorial process involving assembly of thousands of proteins in a precise and synchronized manner over the course of development of an organism. Multiple genes and signalling ... -
Understanding the Mechanism of Double-strand Break Repair and Genome Fragility in Mammalian Mitochondria
Mitochondria are semiautonomous organelles in a cell as they have their own genome that replicates independently. It plays a major role in oxidative phosphorylation due to which mitochondrial DNA (mtDNA) is frequently ... -
Scanning mutagenesis studies of HIV-1 Env immunogenicity and structure
Human Immunodeficiency Virus type 1 (HIV-1) is the etiological agent of Acquired Immunodeficiency Syndrome (AIDS). AIDS is a global pandemic with 36.7 million people living with HIV-1 all over the world and approximately ... -
Design, Synthesis, and Bioactivity of Thioamidated Macrocyclic Peptides
The work presented in this thesis describes the comprehensive study related to thioamidated macrocyclic peptides. We study the underexplored class of peptide bond isostere; thioamides in the context of small macrocyclic ... -
Unraveling the role of cellular phosphatases in lysosome function and storage diseases
Eukaryotic cellular pathways are maintained and coordinated through biomolecule turnover, which includes synthesis, trafficking, degradation of cellular components and their reutilization. The process of biomolecule ... -
Elucidating the mechanism of interaction of Salmonella with plants
Salmonella, is an established pathogen of members of the kingdom Animalia. Its principal species S. enterica serovars Typhi, Paratyphi and Typhimurium can cause various diseases ranging from typhoid fever to gastroenteritis ... -
Intrasexual competition in females of a socially polygynous lizard, Psammophilus dorsalis
Competition between individuals of the same sex, intrasexual competition, has received much attention in males, mainly because such competition, which is primarily for mates (i.e. sexual selection), often selects for ... -
Division of the Salmonella Containing Vacuole and Other Virulence Strategies Employed by Salmonella
Salmonella comprises a genus of rod-shaped, Gram-negative, non-sporulating and primarily motile enterobacteria. They have remained a major cause of morbidity and mortality worldwide, claiming several hundreds of lives per ... -
Structure-Function Analysis of Focal Adhesion Protein Vinculin in Neocortical Axon Growth and Development
Axon growth and extension are dependent on the interaction of neurons with extracellular matrix (ECM). The interaction between cells and ECM is known as focal adhesion (FA). Vinculin is one the major proteins of FA complex ... -
Insights into the Regulation of Transcription Initiation of DNA Gyrase and Role of Transcription Factor Gre from Mycobacterium tuberculosis
Genus Mycobacterium comprises a large number of species including many pathogens such as Mycobacterium leprae, Mycobacterium abscessus and Mycobacterium tuberculosis (Mtb), the last one is the causative agent of the fatal ... -
Understanding the Functions of Nucleoid Associated Proteins in Mycobacterium tuberculosis
The prokaryotic genome, though lacks a membrane bound organelle for its housing, is restricted to only about 25% of the cytoplasmic space called the nucleoid. The dramatic compaction required for the genome to fit in is ... -
Response of Mycobacterium tuberculosis to Hypoxia and its physiological Significance - A Morphological and Molecular Level Study
Mycobacterium tuberculosis (Mtb) has evolved as an important clinical pathogen due to its ability to gain multidrug resistance, to enter into latency to persist there and to get reactivated from the latent infection in ... -
Identification and Characterization of Molecular and Genetic Regulators of Cellular Senescence - Role of Free Radical Homeostasis
Aging is defined in an evolutionary biological context as a steady state decline in the specific fitness components of an organism due to internal physiological deterioration. The most profound and important contribution ... -
Super-Resolution Imaging Reveals Localization and Regulation of Nanoscale Machinery Involved in the Amyloidogenic Pathway
Amyloid Precursor Protein (APP) is a key player in Alzheimer’s disease (AD). Despite intuitive insights into differential proteolysis of APP, there is a little understanding of how the amyloidogenic machinery is distributed ... -
Dynamic colour change in Psammophilus dorsalis: role of natural and sexual selection
Overall, the results from this study support the idea that animal signals arise from a balance between increased conspicuousness for social signalling and inconspicuousness to avoid predation risk. Animals that can change ... -
Intrinsic Noise in Collective Dynamics
Animal groups exhibit many emergent properties that are a consequence of local interactions. Linking individual-level behaviour to group-level dynamics has been a question of fundamental interest from both biological and ... -
An integrative analysis of Cell Adhesion Molecules (CAMs) in Glioma: The Essential role of PTGFRN and ASTN1 in Glioma and Glioma Stem-like Cells
The central nervous system tissue contains neural stem cells which differentiate and give rise to the neurons and glial cells. The glial cells maintain neurons by providing nutrients, physical support and protection. Unlike ... -
Studies on NMPylase and Valine Catabolism Enzymes from Mycobacterium
Post-translational modifications constitute an important arm of the regulatory mechanism in mammalian cells. Therefore, bacterial pathogens, which thrive by mimicking the host cell signaling, are proving to be difficult ... -
Mechanism of β-catenin regulation by IGFBP2: Role in Glioblastoma progression
Insulin-like growth factor binding proteins (IGFBPs) were initially identified as high affinity binders of Insulin-like growth factors (IGFs). There are six IGFBPs which regulate the bioavailability and functions of IGFs ...