Division of Biological Sciences: Recent submissions
Now showing items 281-300 of 1060
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Use of strategically designed protein-like sequences in structure and function recognition
The advent of high fidelity protein sequencing techniques has led to a considerable wealth of sequence data. However, the number of proteins with information on 3-D structure and functional features available is considerably ... -
Functional and structural studies of proteins involved in telomere maintenance
The linear ends of the eukaryotic chromosomes are protected by a specialized nucleoprotein complex known as telomere. Telomeres consist of telomere DNA and telomere DNA binding proteins (known as shelterin complex). The ... -
Dispersal Patterns and Processes in Littorinid Snails along the Indian Coastline
Dispersal has important ecological and evolutionary consequences for a species. Marine dispersal is unique because of facilitation by ocean currents, where oceanography interacts with species traits and environmental ... -
Novel Therapeutic Targets for Alzheimer’s Disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by impaired memory and other cognitive deficits. Even though the genes associated with familial AD were discovered more than three decades ... -
Studies on the post-transcriptional regulation of genes of glutamate utilization pathway in Pichia pastoris and a role for Retrograde regulation protein 1
The methylotrophic yeast, Pichia pastoris can utilize compounds such as glucose, glycerol, methanol, acetate, amino acids, or oleic acid as the sole source of carbon. However, the regulation of synthesis of key enzymes of ... -
Elucidating the role of carbon metabolism genes chiA and yjiY in Salmonella pathogenesis.
Salmonella is a foodborne pathogen that causes debilitating enteric diseases in a wide range of hosts. While Salmonella Typhimurium causes self-limiting gastroenteritis in human beings, Salmonella Typhi causes typhoid fever ... -
Understanding the Significance of Ydcp, a Putative Peptidase Encoding Gene, in Virulence of Salmonella
Salmonella is a recognised enteric pathogen which infects several mammalian and avian hosts through faeco-oral route and establishes either a localised gastrointestinal inflammation and diarrhoea or a systemic fever, ... -
Untangling the Helicobacter pylori genome: Deciphering the significance of zinc finger motif(s) in Topoisomerase I catalysis
Helicobacter pylori, a human pathogen dominating gastric microbial population, displays differential gene expression during various stages of stomach colonization. Topoisomerases play a crucial role in maintaining DNA ... -
Establishment of human ectopic liver tissue in immunocompromised mice as a model for Hepatitis C Virus studies
Infection with hepatitis C virus (HCV) leads to an inflammatory condition which may progress to liver cirrhosis and in some cases, hepato-cellular carcinoma. Though, new drugs are being added to the list of HCV therapeutics, ... -
Immunomodulatory effects of 7-hydroxy frullanolide, a plant-based sesquiterpene lactone, in inhibiting immune cell responses and roles of disease and vaccination outcomes on Covid-19 mortality
Immunomodulation is a process by which the immune response of the host is either enhanced or suppressed due to various factors which either protects or makes the host more susceptible to particular diseases. Immunomodulators ... -
A molecular systems approach to unravel mechanisms and targets in antifolate-resistant bacteria and cancers
Antifolates such as trimethoprim (TMP) and methotrexate (MTX) widely used for treating bacterial infections and certain cancers respectively, inhibit dihydrofolate reductase (DHFR) in the folate pathway. However, the use ... -
Investigating the redox signaling mechanisms during HIV-TB co-infection
Oxidative stress has been at the forefront of HIV/AIDS-related pathophysiologies since the early days of its discovery. Overcoming HIV-1 latency, wherein, the virus remains integrated in the host chromatin, undetected and ... -
Investigating the mechanisms of cancer drug resistance
Clinical chemo-resistance has posed a challenge to scientists and clinicians since the development of chemotherapeutics as anticancer strategy. Mechanisms of drug resistance continue to be a subject investigation amongst ... -
Large Herbivore Dung Decomposition: Effects on Nutrient Cycling in a Tropical Forest of Southern India
Large herbivores can selectively feed on nutrient rich resources, resulting in regular deposition of high quality organic matter in the form of dung. In tropical forests such as in southern India it is estimated that large ... -
Through the looking glass: Phoresy as seen in the light of mutualism
Phoresy is the dispersal of small organisms on larger ones to move out of an unfavourable habitat. Although these interactions are transient, they can form tight links with mutualistic interactions if the phoretic organisms ... -
Structural and mechanistic studies on Staphylococcal RNA degrading enzymes and multienzyme complexes
RNA degrading enzymes and multi-enzyme complexes govern a variety of cellular processes. The role of these enzymes and multi-enzyme assemblies has been suggested to govern gene expression levels in bacteria with modulations ... -
Towards precision medicine to detect, characterize and treat liver cancer: Large-scale data analyses using genome-wide networks
In summary, various systems biology approaches were applied to identify a potential genesignature set to monitor CLD progression which can help in the early detection of HCC. An unbiased analysis of metabolic alterations ... -
Structural and functional studies on DNA damage inducible protein 1 (Ddi1) from protozoa
Structural and functional investigations on DNA-damage inducible protein1 (Ddi1) from Entamoeba histolytica, Trypanosoma cruzi and Toxoplasma gondii have been carried out. Ddi1 belongs to the ubiquitin receptor family of ... -
Computational Investigation of Heterogeneous Lateral Organisation in Biological Membrane
The study of lateral heterogeneity on membrane surface has come a long way from the fluid mosaic model. Simulations and experimental studies have observed non-random mixing of lipids and proteins in the membrane. In this ... -
SRF regulates the generation of neuroprotective astrocytes in the brain
In response to injuries, infections or in neurodegenerative disorders, astrocytes get activated to become reactive. This phenomenon is called astrogliosis and is marked by a spectrum of changes which encompasses structural, ...