Division of Biological Sciences: Recent submissions
Now showing items 221-240 of 1030
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Biochemical characterization of UvrD helicase and its 1 interplay with DNA mismatch repair proteins in 2 Neisseria gonorrhoeae
UvrD helicase belongs to type I superfamily of helicases. It participates in Nucleotide Excision Repair (NER) and DNA Mismatch Repair (MMR). It also participates in the rolling circle replication. It has been shown that ... -
Structural and functional studies on a small Heat Shock Protein from Entamoeba histolytica
Small Heat Shock Proteins (sHSPs) are molecular chaperones that bind to unfolding proteins during cellular stress to prevent them from aggregation. Once the normal conditions are restored, sHSPs release the bound substrate ... -
The role of Rv1860 from M. tuberculosis in modulating the host immune response
Tuberculosis continues to prevail as the major cause of mortality from any single pathogen around the world, despite implementation of control programs and the availability of effective drugs and the vaccine BCG. Mycobacterium ... -
Investigating DNA structural basis for fragility during chromosomal translocations associated with human B-cell lymphomas
Genome integrity is essential for normal cellular functions. Erroneous repair of DNA double-strand breaks (DSBs) could lead to chromosomal rearrangements, including chromosomal translocations that may result in altered ... -
Role of SIRT6 in the Regulation of Glucose Metabolism and Fatty Acid Uptake in Heart
The adult heart heavily relies on fatty acid for most of its energy supplies. The heart derives most of the fatty acid from circulation. Hence, fatty acid uptake forms a crucial step in cardiac metabolism. Studies have ... -
Soil microorganisms and biogeochemical cycles in a grazing ecosystem: interactions between producers, consumers, and decomposers
Microorganisms are the unseen majority that determines ecosystem processes, they perform biogeochemical functions that translate into essential services, and regulate global climate. In grazing ecosystems, which represent ... -
Biogeography and comparative phylogeography of freshwater snails of India
Distribution of flora and fauna is shaped by both current and historical processes. In my thesis I concentrated on how the historical component of the governing processes have dictated the current distribution of biota. ... -
Design of soluble and particulate immunogens derived from the stem of Influenza hemagglutinin
Influenza is a highly contagious virus, belonging to the family Orthomyxoviridae that causes acute febrile respiratory illness which can be fatal in some cases. The highest risk groups for influenza viral infection ... -
Deciphering the evolutionary significance of maintaining cryptic genetic systems by bacteria
Cryptic genes are phenotypically silent DNA sequences with the potential to code for a function, but remain inactive during the normal life span of the organism. However they can be activated by a single mutational event ... -
Use of sub-family specific residues of protein modules in recognizing sites of functional and structural specialization
Functional and regulatory features of a protein in a living system are determined by several factors such as chemical nature and three-dimensional arrangement of residues in the functional site, spatial and temporal ... -
Molecular basis of attenuation of the live attenuated Japanese encephalitis virus vaccine SA14-14-2
Japanese encephalitis virus is a member of Flaviviridae family. Flaviviridae family has four genera which comprises of Flavivirus, Pestivirus, Hepacivirus and Pegivirus. The global burden of disease caused by these viruses ... -
A place for everything and everything in its place: Spatial organization of wasps on the nests of the primitively eusocial paper wasp Ropalidia marginata
In my thesis, I found that queens and workers in the primitively eusocial paper wasp Ropalidia marginata use space on their nests non-randomly with a majority of individuals showing spatial fidelity to small core areas, ... -
Integration of sequences, structures, dynamics to study functional divergence in homologous proteins and their assemblies
Functions of proteins are governed by their sequences, structures, dynamics and assembly. Modulation of these factors during evolution renders functional divergence in related proteins that have originated from the common ... -
Stereochemical studies on peptide and protein structures: Implications for validation, flexibility, and dynamics
Accuracy of 3-D structures of proteins is crucial, both in terms of its agreement with the experimental data used to determine the structure and stereochemistry, especially when they are utilized for applications like drug ... -
Regulation of Lateral Mobility of Amyloid Precursor Protein by an Alzheimer’s Disease Risk Gene: Picalm
Amyloid Precursor Protein (APP) is implicated in several functions in neurons, but the altered processing of APP in synapses holds a key to understanding the onset of the molecular progression of Alzheimer’s Disease (AD). ... -
Understanding the structural organization of the carrier translocase machinery in regulating mitochondrial biogenesis and organelle quality control
Mitochondria are essential eukaryotic organelles required for diverse cellular functions including, energy homeostasis, iron-sulfur cluster biogenesis, and signaling. Therefore, the maintenance of organelle quality control ... -
Diversity from the Gut to Species: Phylogeny, Population genetics and Microbiome of the Antilope cervicapra
Evolutionary relationships between members of the Antilopina taxon have been much debated in recent years. The ‘true antelope’ clade is currently comprised of 4 genera viz., Gazella, Nanger, Eudorcas and the monotypic genus ... -
Investigating Partners of OsMADS1 Transcription Factor and functions for some associated factors for roles in rice inflorescence and floral development
Title: Investigating Partners of OsMADS1 Transcription Factor and functions for some associated factors for roles in rice inflorescence and floral development The classic ABCDE model for floral organ identity show that ... -
Single-channel studies on human TREK-1 (hTREK-1) channels to intracellular ischemia related factors
TREK-1, a member of the two-pore domain family of potassium channels, majorly contributes to the maintenance of resting membrane potential of a cell and has been reported to respond to ischemic levels of intracellular ... -
Host responses in Fas-deficient autoimmune-prone lpr mice upon Salmonella Typhimurium infection
Autoimmune diseases can potentially pre-dispose an individual to infections. On the other hand, infections can trigger, exacerbate or ameliorate autoimmunity. Autoimmune Lymphoproliferative Syndrome (ALPS) is a rare genetic ...