Division of Biological Sciences: Recent submissions
Now showing items 221-240 of 1085
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Influence of Tgf-B on Mechanobiology of Human Breast Cancer Cells
Breast cancers are characterized by extensive modifications to mechanical properties of the tissue via increased ECM production and vascularization. TGF-B is a multi-functional cytokine that is implicated in cancer invasion ... -
Understanding the Role of SIRT2 in Cardiac Hypertrophy, Cell Death and Glucose Homeostasis
Over the last century the major causes of human deaths and ailments has shifted from acute infectious diseases to chronic aging related disorders like cancer and type-2 diabetes. The aging process is a universal property ... -
Dissecting the role of Ataxin 2 Binding Protein 1 in sarcomeric protein stoichiometry and generation of muscle diversity in Drosophila melanogaster
Drosophila muscles are an excellent model to study muscle development, diversity and function. Drosophila muscles consist of two major types –1. Indirect Flight Muscles (IFM), that are fibrillar; as opposed to other tubular ... -
Production of taxol from Lasiodiplodia theobromae and biochemical characterization of its 10-deacetylbaccatin III-10-O-acetyltransferase enzyme and evaluation of anticancer activity of enzymatically synthesized baccatin III
Taxol (paclitaxel) originally identified from the inner bark of Taxus brevifolia, is a clinically approved anticancer drug for the treatment of various kinds of cancer, particularly ovarian cancer, breast cancer and Kaposi's ... -
Structural Correlates of Related Contextual Learning in Retrosplenial Cortex
The discovery of dendritic spines by Santiago Ramón y Cajal is one of the most important chapters in the history of neuroscience. Apart from establishing the neuron doctrine, it presented dendritic spines as the information ... -
Studies on differentiation of mouse GS-2 ES-cells to pancreatic β-islet-like cells and their functional maturation status
Embryonic stem cells (ES-cells) are an excellent source for generating insulin-producing β-islet cells for potential use in the management of diabetes mellitus. Although many protocols have been developed to promote the ... -
Studies on Nudix hydrolase proteins and crosstalk between DNA repair pathways
Mycobacterium tuberculosis, the causative agent of tuberculosis, has become a global health concern. This calls for a dire need to understand various aspects of mycobacterial physiology in order to design better strategies ... -
Condition-dependent signalling and mating behaviour in the tree cricket, Oecanthus henryi
Male reproductive success in systems exhibiting sexually selected traits can be driven by male mating effort in sexual signals and in the production of nuptial gifts. Male mating effort can be determined by various biotic ... -
Multi-faceted modular interactions in proteins
All living systems are composed of plethora of biomolecules. There are various types of biomolecules such as proteins, DNA, RNA, carbohydrates and metabolites. All the reactions in a biological system involve interactions ... -
Functional characterization of Salmonella Typhimurium encoded Cold Shock Protein E during stress responses, biofilm formation and virulence
Overall, this study reports novel functional roles of S. Typhimurium encoded CspE during bile resistance, biofilm formation and in vivo virulence. It also establishes importance of an uncharacterised protein YciF, implicating ... -
Insights into the Differential Cytotoxicity of Abrin and Design of a Vaccine Candidate against the Toxin
Ribosome inactivating proteins (RIPs) from plants, fungi or bacteria are extremely lethal due to their N-glycosidase activity on eukaryotic ribosomal RNA. As the name indicates, these toxins inactivate ribosomes; thereby ... -
Neural Correlates and Behavioral Underpinnings of Remote Memories during Systems Consolidation
Remote retrieval of declarative memories has been under investigation for a long time. After acquisition, long-term encoding of memories happens through crosstalk across multiple brain regions. Through systems consolidation, ... -
A role for the cohesin complex in subtelomeric gene silencing in Saccharomyces cerevisiae
Chromatin is a dynamic structure which reorganizes to support numerous chromosomal processes. Various histone and non-histone proteins are involved in chromatin organization. One such group of non-histone proteins, known ... -
Improving Glioblastoma Management: A Study of Biomarkers, Tumor Microenvironment and Chemoresistance
Glioblastoma (GBM) is an aggressive form of adult brain tumors. The current standard of care includes maximal safe resection followed by concurrent chemo-radiation therapy and adjuvant chemotherapy with temozolomide. ... -
New insights into the role of condensin in Saccharomyces cerevisiae
Structural Maintenance of Chromosomes (SMC) complexes are highly conserved from prokaryotes to eukaryotes. Saccharomyces cerevisiae has six SMC proteins which form three SMC-complexes in association with non-SMC subunits ... -
Regulation of RecA nucleoprotein filament stability by RecX and the effects of RecA-membrane interaction on the activities of RecA in mycobacteria
E. coli RecA is a multifunctional protein known to be associated with the cell membrane, forming foci often located at the cell poles, which gets redistributed along the length of the cell during SOS response. Several lines ... -
Altering DNA topology in mycobacteria: impact of perturbation of DNA gyrase on physiology and gene expression
In the current dissertation, efforts have been made to probe the in vivo role of DNA gyrase to determine its importance in the growth, physiology and gene expression in mycobacteria. In this dissertation, the role of DNA ... -
Estimation of the spatial spread of brain signals at multiple scales
Spatial spread of a particular brain signal can be defined as the area of the cortical tissue around the recording electrode that contributes to the electrical activity recorded by the electrode. More specifically, ... -
Biochemical, Genetic and Molecular characterization of TCP3 and TCP4 transcription factors in Arabidopsis thaliana
The TEOSINTE BRANCHED1, CYCLOIDEA, PROLIFERATING CELL FACTORs (TCP) family of proteins consists of plant-specific, non-canonical basic helix-loop-helix transcription factors that perform diverse developmental processes. ... -
Aβ42-mediated dendritic spine loss in an in-vitro model of Alzheimer’s disease
The results from this study establish the molecular mechanism underlying the Aβ42-mediated dendritic spine loss observed in the APP/PS1 mouse model of AD. Further, this study highlights the role of Aβ42 in altering the ...