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Analysis Of Protein Evolution And Its Implications In Remote Homology Detection And Function Recognition
(2009-07-22)
One of the major outcomes of a genome sequencing project is the availability of amino acid sequences of all the proteins encoded in the genome of the organism concerned. However, most commonly, for a substantial proportion ...
Computational And Biochemical Studies On The Enzymes Of Type II Fatty Acid Biosynthesis Pathway : Towards Antimalarial And Antibacterial Drug Discovery
(2009-08-13)
Malaria, caused by the parasite Plasmodium, continues to exact high global morbidity and mortality rate next only to tuberculosis. It causes 300-500 million clinical infections out of which more than a million people succumb ...
Structural Studies On The Enzymes FabI And FabZ Of Plasmodium Falciparum
(2008-10-20)
The thesis deals with X-ray crystallographic analysis of two enzymes involved in the fatty
acid biosynthesis pathway, known as Fatty Acid Synthase or FAS, of the malarial parasite, Plasmodium falciparum, in order to ...
Biochemical And Molecular Insights Into β-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ) From Plasmodium Falciparum
(2008-10-14)
Malaria, caused by Plasmodium, is one of the most devastating infectious diseases of the world in terms of mortality as well as morbidity (WHO, 2002). The development of resistance in the Plasmodium falciparum against the ...
Identification Of Chloroquine Resistant Haplotypes Of Plasmodium Falciparum In India And Development Of New Antimalarial Combinations
(2008-10-03)
Malaria afflicts 300-500 million people in the world and the mortality ranges from 1-2
million, children in Africa being the most susceptible. With a vaccine not being
available against malaria and the front line drugs ...