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Designed β-Hairpin, β-Sheet And Mixed α-β Structures In Synthetic Peptides
(Indian Institute of Science, 2007-03-16)
Synthetic construction of protein molecules has been widely pursued over the last two decades. A primary goal behind de novo protein design has been to build minimal systems by capturing the essential features of protein ...
Structural Studies On Winged Bean Agglutinins
(Indian Institute of Science, 2007-01-11)
Lectins are multivalent carbohydrate binding proteins that specifically recognise diverse sugar structures and mediate a variety of biological processes, such as cell-cell and host-pathogen interactions, serum glycoprotein ...
Stringent Response In Mycobacteria: Molecular Dissection Of Rel
(2007-11-29)
Adaptation to any undesirable change in the environment dictates the survivability of many microorganisms. Such changes generate a quick and suitable response, which guides the physiology of bacteria. Stringent response ...
Mechanism Of Anticancer And Antimalarial Action Of A Modulator Of Heat Shock Proteins
(2007-11-16)
This thesis entitled “Mechanism of Anticancer and Antimalarial Action of
a Modulator of Heat Shock Proteins” describes the successful elucidation of the
mechanism of anticancer and antimalarial action of 15-Deoxyspergualin ...
Structural Studies On Enzymes From Salmonella Typhimurium Involved In Propionate Metabolism: Biodegradative Threonine Deaminase, Propionate Kinase And 2-Methylisocitrate Lyase
(2007-11-23)
I formally joined Prof. M. R. N. Murthy’s laboratory at the Molecular Biophysics
Unit, Indian institute of Science, on 1st August 2001. During that time, the interest in the laboratory was mainly focused on structural ...
Molecular Analysis Of Hamster Sperm Capacitation: Significance Of Protein Tyrosine Phosphorylation
(2007-12-17)
Fertilization is a process that generates the first cell of a new organism. In mammals,
fertilization occurs in the female reproductive tract. The male gametes (spermatozoa) are rendered fertilization-competent only after ...
Studies On The Phenomenon Of Blastocyst Hatching: Role Of Cysteine Proteases
(2007-11-16)
The mammalian embryo is encased in a glycoproteinaceous covering, the
zona pellucida (ZP/zona) during preimplantation development. Prior to
implantation into the recipient maternal endometrium, the blastocyst has to
hatch ...
Mechanism Of mom Gene Transactivation By Transcription Factor C Of Phage MU
(Indian Institute of Science, 2007-04-26)
Regulation of transcription initiation is the major determining event employed by the cell to control gene expression and subsequent cellular processes. The weak promoters, with low basal transcription activities, are ...
Functional Characterization Of The Saccharomyces Cerevisiae Splicing Factor, Prp17 In pre-mRNA Splicing And Cell Cycle Progression: An Analysis Through Global Expression Profiling, Protein Interactions And Spliceosomal Associations
(2007-08-30)
The presence of introns in all the eukaryotic genomes identified so far underscores the fundamental and ubiquitous role of pre-mRNA splicing. The spliceosomal machinery, comprised of five small nuclear RNAs and several ...
Structure Function Studies Of Biologically Important Simple Repetitive DNA Sequences
(Indian Institute of Science, 2007-03-09)
The recent explosion of DNA sequence information has provided compelling evidence for the following facts. (1) Simple repetitive sequences-microsatellites and minisatellites occur commonly in the human genome and (2) these ...