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Exploring the roles of nucleoid-associated protein HU and two of its interacting proteins in Mycobacterium tuberculosis pathogenesis
The genome in prokaryotes is restricted to a membrane-less compartment termed nucleoid. The genome is maintained in the compacted state within the nucleoid with the help of three key cellular factors viz, macromolecular ...
Epigenetic modulation of Foam cell generation during Mycobacterium tuberculosis/ Cryptococcus neoformans infection
Foamy macrophages or Foam cells are a critical cellular component of the granuloma formed during pulmonary infection. These lipid rich cells generally contain neutral lipids, Cholesteryl Esters (CE) and/or Triglycerides ...
Studies on Nudix hydrolase proteins and crosstalk between DNA repair pathways
Mycobacterium tuberculosis, the causative agent of tuberculosis, has become a global health concern. This calls for a dire need to understand various aspects of mycobacterial physiology in order to design better strategies ...
Molecular insights into the regulation of host unfolded protein response and angiogenesis during Mycobacterium tuberculosis pathogenesis
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), continues to co-evolve with the human population, rendering it one of the most significant global health threats among infectious diseases. The ...