Receptor guanylyl cyclase C (GC-C, gene GUCY2C) is expressed on the apical surface of the intestinal epithelial cells and gets activated by the endogenous ligands guanylin and uroguanylin. Heat-stable enterotoxin (ST) ...

Trichomonas vaginalis is a protozoan parasite and the causative agent of the most common non-viral, sexually transmitted disease (STD) in humans known as trichomoniasis. WHO estimates more than 270 million cases of ...

Oligodendrocytes (OLs), a type of glial cell, are the main myelinating cells of the mammalian central nervous system (CNS), enabling efficient saltatory mode of nerve conduction. On the other hand, astrocytes, another glial ...

Polarity establishment is critical for the development and stem cell lineages. The one-cell stage of the Caenorhabditis elegans embryo polarizes soon after fertilization. As a result, the first division of the embryo ...

Swarming, in bacteria, is a type of group translocation phenomenon observed in several flagellated species characterized by their ability to spread across solid or semi-solid surfaces rapidly – often with a distinct colony ...

AMP-activated kinase (AMPK) is an energy sensor that regulates cell growth and metabolism. Reports from our laboratory and others have shown the context-specific role of AMPK signaling in breast cancer. However, its role ...

Urolithin-A mitigates synaptic dysfunctions associated with epilepsy through VDAC1 inhibition: A novel therapeutic approach Epilepsies are a group of neurological disorders with a prevalence of 70 million people worldwide ...

Salmonella Typhimurium (S. Typhimurium) is an enteric pathogen that causes gastroenteritis. Although gastroenteritis is usually non-life threatening in healthy adults, it can cause fatality in children and immunocompromised ...

Mycobacterium smegmatis, a soil bacterium, faces multiple challenges in its environment, including exposure to reactive oxygen species (ROS), reactive nitrogen intermediates (RNI), radiation, and various other chemical ...

The DNA in our cells is under constant threat from various exogenous and endogenous sources. To ensure error free and faithful transmission of hereditary material, human cells employ several DNA repair pathways. Mammalian ...