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Pranlukast as an Allosteric Inhibitor of M.Tuberculosis Ornithine Acetyltransferase : Implication Towards Novel Combinatorial Therapy
Tuberculosis (TB) is a deadly disease responsible for the death of approximately 1.5 million people each year, with the highest being from developing nations. Tuberculosis affects mostly the lungs, and other parts of the ...
Understanding the Role of ThiJ/DJ-1/PfpI Family Member Proteins in Regulating Redox Homeostasis, Mitochondrial Health and Lifespan in Saccharomyces cerevisiae
In a healthy cell, the ROS levels are stringently regulated by the action of various enzymatic or non-enzymatic antioxidant systems. Imbalance in the ROS homeostasis generates oxidative stress resulting in damage to cellular ...
Structural Studies on Non-toxic Homologues of type II Ribosome Inactivating Proteins (RIPs)
This thesis is concerned with structural and related studies on two non-toxic homologues of type II RIPs. Type II RIPs, which are more toxic than type I, contain an additional lectin chain (B-chain) covalently linked to ...
Exploration of the Recombination Repair Pathway in Mycobacteria : Identification and Characterization of New Proteins
Genomic integrity is a fundamental requisite for survival and proliferation of all organisms.
The genetic material is continuously threatened by a multitude of extrinsic and intrinsic factors. Consequently, the presence ...
Regulation of Host Innate Immune Responses by Hippo Signaling Pathway during Pattern Recognition Receptors (PRRs) Driven Inflammation : Implication for Host-Pathogen Interactions
Innate immunity refers to the first line of defence system of the host that comes into play immediately or within hours of appearance of invading pathogens like bacteria, viruses and fungi. Cells of the innate immune system ...
Molecular Insights into the Structure and Function of Pepper Vein Banding Virus Encoded Proteins and Endocytic Uptake Pathway of Virus-like Particles into Mammalian Cells
Viruses are major pathogenic agents that cause a variety of diseases in all living systems. Since their first isolation in 1892 by Dimitrii Ivanovsky, methods of their diagnosis and control, their life cycles, host - virus ...
Elucidating Deregulated Novel Pathways in Glioma through Genetic and Epigenetic Approaches
Malignancy of glial cells is termed as glioma. Gliomas comprise of thirty percent of
all tumors of the central nervous system (CNS) and eighty percent of malignant brain tumors
(Goodenberger and Jenkins, 2012). Astrocytoma, ...
Structural and Biochemical Studies on Mycobacterial Uracil- DNA N-glycosylase and Mut T1
Maintenance of the genomic integrity of the cell is crucial for the survival and successful propagation of an organism. However, this integrity is under continuous threat from DNA-damaging agents. In addition, errors in ...
Structural Characterization of Biological Macromolecules by Random Conical Tilt Pair Experiments
Structural biology deals with determining the structure of biological macromolecules
especially proteins, DNA, RNA. The conformational changes in the structure of a
macromolecule helps to decipher its function. This ...
Understanding the Role of Lsm Domain in Translation Repression Activity of RGG-motif Containing Protein Scd6
Control of gene expression in eukaryotes is regulated at various steps such as transcription, translation and protein degradation. Translation repression of mRNA regulates protein levels and maintains cell homeostasis. ...