TREK1 is a two-pore domain leak potassium channel which contributes to resting membrane potential. TREK1-/- mice exhibit increased neuronal mortality after global ischemia. Neuroprotective agents like volatile anesthetics ...

Bacteria face the challenging task of compacting their chromosomes to accommodate them in a small cytoplasmic volume and at the same time maintaining the nucleoids in a highly organized and dynamic state for transcription, ...

Single-stranded RNA virus infection cycle progresses by resource (viral RNA) allocation to segregated macromolecular complexes: host ribosomes (translation), viral RNA polymerase (replication) and viral structural proteins ...

Tuberculosis is the second largest killer disease on global scale after HIVAIDS. The rapid evolution of Mycobacterium tuberculosis into drug resistant strains and the toxicity of these drugs are the major constraints in ...

Sirtuins and PARPs are stress responsive family of proteins regulating genome instability, inflammation, aging-related diseases and energy metabolism. Both sirtuins and PARPs are NAD+ enzymes with deacetylase and ADP-ribose ...

Tuberculosis, which is caused by Mycobacterium tuberculosis (Mtb), is viewed to be the predominant cause of death arising due to bacterial infection. Further, the emergence of MDR/XDR strains and co-infections has compounded ...

Chronic inflammatory disorder is one of the leading causes of death worldwide. Association between pathogenic infection and inflammation governs tissue homeostasis, which relies on extensive crosstalk among signaling ...

Cells are constantly engaged in the process of making and breaking proteins in a highly organized manner. However, protein synthesis is an energetically expensive process and often competes with other cellular repair and ...

Developmental pathways such as Notch are known to regulate self-renewal and cell fate decisions in embryonic and adult tissue-specific stem cells, while deregulation of Notch signalling is associated with malignant ...

The studies reported in this thesis address the physiological role of an antibiotic resistance gene arr, followed by establishment of the arr knockout strains (generated during the investigation) for drug testing and ...