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Effect of Ultrasound on Neuronal Network Communication
(2018-05-22)
Low intensity and low frequency ultrasound has been shown to modulate ion channel currents, membrane capacitive currents, and as a result, neuronal activity. Ultrasound has been used as a non-invasive way to modulate ...
Ischemic Concentrations of Lactate Increase TREK1 Channel Activity and Expression
TREK1 is a two-pore domain leak potassium channel which contributes to resting membrane
potential. TREK1-/- mice exhibit increased neuronal mortality after global ischemia. Neuroprotective agents like volatile anesthetics ...
Pharmacological Modulation Of Recombinant Human Two-Pore Domain K+ Channels : Whole-Cell patch-Clamp Analysis
(2011-10-21)
Background potassium currents play an important role in the regulation of the resting membrane potential and excitability of mammalian neurons. Recently cloned two- pore domain potassium channels (K2p) are believed to ...
Intracellular Calcium Dynamics In Dendrites Of Hippocampal Neurons Rendered Epileptic And In Processes Of Astrocytes Following Glutamate Pretreatment
(2009-04-03)
The fundamental attribute of neurons is their cellular electrical excitability, which is based on the expression of a plethora of ligand- and voltage-gated membrane channels that give rise to prominent membrane currents ...
Collective escape dynamics of fission-fusion groups in the wild
Collective movement is a fundamental process affecting the survival and reproductive success of group-living animals. Many of the hypothesized benefits of grouping such as predation evasion and foraging efficiency may ...
Role of Mycobacterium tuberculosis UvrD1 and UvrD2 helicases in resolving G-quadruplex DNA structures
Unresolved G-quadruplex (G4) DNA secondary structures impede DNA replication and can lead to DNA breaks and to genome instability. Helicases are known to unwind G4 structures and thereby facilitate genome duplication. ...
PP2A-phosphatase and Polo-like kinase 1 regulates spindle positioning by orchestrating the cortical levels of the dynein adaptor NuMA
The mitotic spindle is a microtubule-based diamond shape structure that captures
chromosomes and facilitates their segregation during anaphase. Proper positioning of
the mitotic spindle is critical for defining the ...
Role of Lysyl oxidase in TGF-beta-induced Fibroblast Activation and Cancer-Associated Fibroblast-mediated Breast Cancer Progression
Cancer-associated Fibroblasts (CAFs) are a dominant cell type of the breast cancer microenvironment and are proposed to be involved in metastatic progression. TGF-β has been reported to influence fibroblast to myofibroblast ...
Understanding the regulation of translation and replication of Coxsackievirus B3 RNA by host RNA binding proteins
Coxsackievirus B3 (CVB3) is an enterovirus, with a positive-sense single-stranded RNA genome. The genome contains a single open reading frame (ORF) flanked by untranslated regions (UTR) at the 5’ and 3’ ends. The viral ...