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Roles of the ribosomal protein uS12 and the initiation factor 3 in the maintenance of fidelity of translation in Escherichia coli
The flow of genetic information within biological systems according to the central dogma of molecular biology entails protein synthesis as the last step towards deciphering the message encrypted in the genetic code in ...
Role of Mycobacterium tuberculosis UvrD1 and UvrD2 helicases in resolving G-quadruplex DNA structures
Unresolved G-quadruplex (G4) DNA secondary structures impede DNA replication and can lead to DNA breaks and to genome instability. Helicases are known to unwind G4 structures and thereby facilitate genome duplication. ...
Cholinergic-receptor-independent modulation of intrinsic properties of subicular neurons through inhibition of hyperpolarization-activated cyclic nucleotide-gated channels
Acetylcholine release is vital in tuning the hippocampal theta oscillations. Subiculum, the output
region of the hippocampus endowed with different neuronal subtypes, also generates theta oscillations
during arousal and ...
Stereochemical studies on peptide and protein structures: Implications for validation, flexibility, and dynamics
Accuracy of 3-D structures of proteins is crucial, both in terms of its agreement with the experimental data used to determine the structure and stereochemistry, especially when they are utilized for applications like drug ...
PP2A-phosphatase and Polo-like kinase 1 regulates spindle positioning by orchestrating the cortical levels of the dynein adaptor NuMA
The mitotic spindle is a microtubule-based diamond shape structure that captures
chromosomes and facilitates their segregation during anaphase. Proper positioning of
the mitotic spindle is critical for defining the ...
CcdB : Stability, folding and application to design novel antibacterials
The primary amino acid sequence typically dictates the ultimate conformation of the protein. Mutations in the sequence demonstrate neutral, positive or negative effects on the structure-function relationship of the protein. ...
Structural and DNA binding properties of ARID domains present in hSWI/SNF chromatin remodeling complex subunits
The SWI/SNF complexes are multisubunit-containing protein complexes that are involved in chromatin-remodeling processes in the eukaryotic cells. In higher eukaryotes, SWI/SNF complexes contain one or more mutually exclusive ...
Collective escape dynamics of fission-fusion groups in the wild
Collective movement is a fundamental process affecting the survival and reproductive success of group-living animals. Many of the hypothesized benefits of grouping such as predation evasion and foraging efficiency may ...
Investigation of RAG1 in lymphoid and brain cells: Understanding mechanism and regulation
In summary, we show that RAG1 expression is regulated through a novel miRNA (miR-
29c) mediated mechanism and establish that as an additional mode of RAG1 regulation.
Studies described in the thesis reveal that among the ...
Investigating DNA structural basis for fragility during chromosomal translocations associated with human B-cell lymphomas
Genome integrity is essential for normal cellular functions. Erroneous repair of DNA double-strand breaks (DSBs) could lead to chromosomal rearrangements, including chromosomal translocations that may result in altered ...