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Scanning mutagenesis studies of HIV-1 Env immunogenicity and structure
Human Immunodeficiency Virus type 1 (HIV-1) is the etiological agent of Acquired Immunodeficiency Syndrome (AIDS). AIDS is a global pandemic with 36.7 million people living with HIV-1 all over the world and approximately ...
Deciphering the genetic regulators of cuticle barrier function and longevity in Caenorhabditis elegans
Ever since Sydney Brenner introduced Caenorhabditis elegans in the early 60s as a
model system, this worm has contributed to many ground-breaking discoveries in
science. It has served as an excellent model to study animal ...
Structural Studies on the Intracellular Steps that Govern the Staphylococcus aureus Quorum Sensing System.
Quorum sensing in bacteria has been extensively examined over the past two decades. These studies suggest that the molecular mechanism that governs quorum sensing incorporates niche-specific, environmentally sensitive ...
SRF regulates the generation of neuroprotective astrocytes in the brain
In response to injuries, infections or in neurodegenerative disorders, astrocytes get activated to become reactive. This phenomenon is called astrogliosis and is marked by a spectrum of changes which encompasses structural, ...
The influence of landscape composition on butterfly populations: A behavioural ecological approach
Overall, taking behavioural ecological and trait-based approaches, my study suggests that the distribution of a species and patterns in its population densities in a landscape are affected by diverse ecological variables, ...
Proteomics-based Identification of Serum Biomarkers : Role of Secreted MCSF and CRP in Glioma Pathogenesis
Gliomas are the neoplasia of glial cells present in the brain and comprises of
more than 70% of all the neoplasms of the central nervous system. They consist of
a family of primary brain tumors that are categorized based ...
Spatio-temporal Regulation of GPCR mediated MAPK Transactivation in Living Cells
Signal transduction is a mode of cellular communication essential for an organism’s
sustenance and survival. Cell communication in higher organisms is largely executed by
two classes of cell surface receptors i.e. G-protein ...
Patterns and Drivers of Multimodal Signalling in Diurnal Geckos
Effective communication in animals comprise emission of a signal by a signaller and a response by a receiver, such that the interaction is beneficial to either only the signaller, or both the signaller and the receiver. ...
Design, Synthesis, and Bioactivity of Thioamidated Macrocyclic Peptides
The work presented in this thesis describes the comprehensive study related to thioamidated macrocyclic peptides. We study the underexplored class of peptide bond isostere; thioamides in the context of small macrocyclic ...
Functional Characterization of CG9650 in development of the Indirect Flight Muscles of Drosophila melanogaster
Muscle development is a complex and multifactorial process involving assembly of thousands of proteins in a precise and synchronized manner over the course of development of an organism. Multiple genes and signalling ...