The ability to perceive and adapt to environmental fluctuations, both internal and external, is a fundamental characteristic of life across diverse organisms. Within the context of pathogenic bacteria such as Mycobacterium ...

A distinctive feature of the bacterial RNA polymerase is the modular organization. The core of this enzyme, comprised of a dimer of the α subunit assembles with the β, β', and ω subunit. The core RNA polymerase enzyme ...

Oral Squamous Cell Carcinoma (OSCC) or oral cancer is the malignancy of the epithelial lining of the oral cavity. It is the leading cause of cancer-related mortality in Indian males and despite technological advancements, ...

India is considered the world's snakebite capital, where over 58,000 snakebite fatalities are registered annually. Most bites are primarily attributed to four snake species: the spectacled cobra (Naja naja), common krait ...

In the scope of my thesis work, a concerted effort was undertaken to elucidate bi- ological functions through the lens of structural analysis, employing protein dy- namics. The role of protein dynamics in shaping and ...

This thesis involves a detailed structural study of two molecular systems, a small disulfide-rich peptide LL-TIL and a large catalytic subunit of AHAS. Subtilisin inhibitors play an important role in fighting against ...

Pathogenic bacteria employ an array of biological macromolecules and cellular structures that help in the initiation and progression of disease in host organism. These ‘virulence factors’ can either be secreted by the ...

Wound healing is a crucial physiological process required for the healthy lifespan of an organism. Dysregulation in the process of wound healing leads to the production of excess extracellular matrix leading to fibrosis. ...

Major Depressive disorder (MDD) is a complex, multifactorial psychiatric illness which affects over 20% of the population worldwide. Despite its prevalence, our understanding of its pathophysiology is severely limited, ...

Subicular burst firing neurons are established as primary instigators of seizure onset and propagation in Temporal Lobe Epilepsy (TLE), a form of focal epilepsy that accounts for approximately 60% of all epilepsy cases in ...