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GABAA Receptor Mediated Phasic and Tonic Inhibition in Subicular Pyramidal Neurons
(2018-07-28)
GABA is the major inhibitory neurotransmitter in the central nervous system. It binds to two types of receptors –ionotropic GABAA and metabotropic GABAB. The GABAA receptor directly gates a Clionophore that causes ...
Structural and Functional Studies on the Mycobacterium tuberculosis σ factor σJ
(2018-05-21)
Regulation of transcription in prokaryotes is primarily governed at the transcription initiation step. This feature has been extensively characterized in model prokaryotes notably Escherichia coli and Bacillus subtilis. ...
Modulation of Protein Stability and Function by Cysteine Mutations and Signal Peptides
(2018-06-23)
Chapter 1gives a general introduction to the CXXC motif found in natural proteins. It then reviews the studies where disulphides were engineered in various proteins. The various strategies developed to engineer metal binding ...
Structural Feature of Prokaryotic Promoters and their Role in Gene Expression
(2018-05-14)
Transcription initiation is an important step in the process of gene regulation in prokaryotes. Promoters are stretches of DNA sequence that are present in the upstream region of transcription start sites (TSSs), where RNA ...
Structural Investigations Of Sugar-Binding And Multivalency In Peanut Lectin
(2009-03-04)
Starting with the structure analysis of ConA in the 70s, the crystal structures of hundreds of different lectins and their carbohydrate complexes have been determined. Lectins, multivalent carbohydrate-binding proteins ...
Structural and Related Studies on Mycobacterial RecA and LexA
(2018-06-18)
Genetic material of bacteria is subject to damage due to multitudinous factors, both extrinsic and intrinsic in origin. Mechanisms for the maintenance of genomic integrity are thus essential for a bacterium to survive. ...
Understanding the Regulatory Steps that Govern the Activation of Mycobacterium Tuberculosis σK
(2018-07-28)
A distinctive feature of host-pathogen interactions in the case of Mycobacterium tuberculosis is the asymptomatic latent phase of infection. The ability of the bacillus to survive for extended periods of time in the host ...
Development of a Selective Cell-Permeable Protein Phosphatase 1 Inhibitor
(2018-07-10)
Selective ‘super-specific’ inhibitors of Protein Phosphatase 1 (PP1) are not available. Several natural product toxins possessing marginal selectivity between PP1 and the closely related Protein Serine/Threonine Phosphatase ...