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Cyclic AMP In Mycobacteria Adenylyl Cyclases And Cyclic AMP Receptor Proteins
(2013-01-28)
The discovery of cyclic AMP (cAMP), nearly 50 years ago by Sutherland radically altered the appreciation of metabolic regulation. Since then the presence of cAMP and its tremendous physiological impact has been demonstrated ...
Developmental and Functional Roles of Troponin-T Isoforms, and Exploring Genome-Wide Alterations in Drosophila Indirect Flight Muscle Mutants
(2018-05-23)
Muscle contraction is a highly fine-tuned process that requires the precise and
timely construction of large protein sub-assemblies to form sarcomeres, the
individual contractile units. Mutations in many of the genes ...
Unraveling the Mechanism of Luteinizing Hormone Receptor Activation : Hinge Region as a Key Player
(2018-06-05)
GPCRs, influencing myriads of cellular functions, are the members of the largest family of the membrane proteins. However, their structures and the signaling mechanisms still remain enigmatic. In case of the Glycoprotein ...
Stress Signaling In Development And Carcinogenesis : Role Of AMP-Activated Protein Kinase
(2013-08-05)
Rapidly growing tumor cells outgrow their blood supply resulting in a microenvironment with reduced oxygen and nutrients. Using an in vitro transformation model we found that cancer cells expressing the SV40 ST antigen ...
Studies On The Phenomenon Of Blastocyst Hatching: Role Of Cysteine Proteases
(2007-11-16)
The mammalian embryo is encased in a glycoproteinaceous covering, the
zona pellucida (ZP/zona) during preimplantation development. Prior to
implantation into the recipient maternal endometrium, the blastocyst has to
hatch ...
Insights Into Molecular Regulation Of Cardiomyocyte Differentiation Of Mouse Pluripotent Stem Cells
(2015-08-03)
Pluripotent stem cells (PSCs) are specialized cells, which have remarkable ability to maintain in an undifferentiated state and are capable of undergoing differentiation to three germ-layer lineage cell types, under ...
Cyclic AMP-Regulated Protein Lysine Acetylation In Mycobacteria
(2015-07-17)
Tuberculosis continues to be one of the major causes of morbidity and mortality worldwide. Several mycobacterial species such as M. tuberculosis and M. africanum are responsible for causing this disease in humans. Reports ...
Insights Into Cytostatic Mechanisms Regulated By Receptor Guanylyl Cyclase C
(2016-11-16)
All cells are equipped to sense changes in their environment and make adaptive responses according to the stimuli. Signal recognition usually occurs at the cell membrane (with the exception of steroid signalling) where the ...
Gene Expression Profiling And Insights Into The Involvement Of The Insulin Signaling Pathway In Oral Cancer
(2008-08-27)
1. Despite extensive research on oral squamous cell carcinoma (OSCC), its five-year survival rate has not improved for the last two decades. Effective treatment of OSCC requires the identification of molecular targets to ...