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Now showing items 1011-1020 of 1025
Understanding structure, function, and dynamics in macromolecular complexes
In the scope of my thesis work, a concerted effort was undertaken to elucidate bi-
ological functions through the lens of structural analysis, employing protein dy-
namics. The role of protein dynamics in shaping and ...
Solution NMR studies of a potent subtilisin inhibitor from Budgett’s frog and the catalytic subunit of AHAS
This thesis involves a detailed structural study of two molecular systems, a small disulfide-rich peptide LL-TIL and a large catalytic subunit of AHAS.
Subtilisin inhibitors play an important role in fighting against ...
Investigating mechanisms underlying astrocytic involvement in depressive-like behavior and antidepressant action
Major Depressive disorder (MDD) is a complex, multifactorial psychiatric illness which affects over 20% of the population worldwide. Despite its prevalence, our understanding of its pathophysiology is severely limited, ...
Understanding protein structural excursions using residue networks and implications on biological function
The information required for a protein structure to fold into the native conformation is encoded in its sequence. Studying protein structures help to understand their biological function. Molecular interactions between ...
Venomics of Medically Important yet Neglected Elapid Snakes of India and the Antivenomic Potential of Plant Extracts
India is considered the world's snakebite capital, where over 58,000 snakebite fatalities are registered annually. Most bites are primarily attributed to four snake species: the spectacled cobra (Naja naja), common krait ...
Exploring the Marine Algicolous Endophytic Fungi: A Promising Source of Novel Cancer Therapeutics
Cancer is the second leading cause of mortality globally, with over 6 million new cases diagnosed annually. Research on effective therapies is crucial due to the disease's complexity. Natural materials in chemotherapy have ...
Metabolic and Pharmacological Modulations During IFN-γ signaling
Interferons, initially discovered for their antiviral properties, play pivotal roles in various biological processes, including host defense against pathogens, tumor surveillance, and disease pathogenesis. Interferon-gamma ...
Astroglial development as the basis for the effects of early life stress on adult depressive-like behavior
This thesis investigates the enduring effects of early-life stress, specifically maternal separation, on astroglial population and the subsequent behavioral outcomes in adult mice. While the persistent impact of early-life ...
Role of the unstructured N-terminal region and interacting proteins on the function of Mycobacterium tuberculosis σA
A distinctive feature of the bacterial RNA polymerase is the modular organization. The core of this enzyme, comprised of a dimer of the α subunit assembles with the β, β', and ω subunit. The core RNA polymerase enzyme ...
Role of PdtaS-PdtaR two component signalling system in metabolic adaptation in Mycobacterium spp.
The ability to perceive and adapt to environmental fluctuations, both internal and external, is a fundamental characteristic of life across diverse organisms. Within the context of pathogenic bacteria such as Mycobacterium ...