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Risks of finding mates in the wild: Ecological and Behavioural Determinants of Sex-biased Predation
Sex-biased predation occurs when one sex of a prey species is consumed more than the other,
irrespective of their relative availability (sex-ratio). Some of the potential factors leading to sex-
biased predation are sex ...
Establishment of a knock-in mouse model expressing a hypomorphic variant of receptor guanylyl cyclase C
Receptor guanylyl cyclase C (GC-C, gene GUCY2C) is expressed on the apical surface of the intestinal epithelial cells and gets activated by the endogenous ligands guanylin and uroguanylin. Heat-stable enterotoxin (ST) ...
Understanding the adaptive responses of Salmonella Typhimurium during bile stress
Salmonella Typhimurium (S. Typhimurium) is an enteric pathogen that causes
gastroenteritis. Although gastroenteritis is usually non-life threatening in healthy
adults, it can cause fatality in children and immunocompromised ...
Studying the role of small GTPase Rab14 in the regulation of endosomal function
The endomembrane system and their associated membrane trafficking are fundamental
features of eukaryotic cell biology. These processes are regulated by small GTP-binding
proteins that acts as molecular switches to ...
Deciphering the biochemical and biophysical properties of the Holliday junction resolvases RuvC and RuvX from Mycobacterium smegmatis
Homologous recombination (HR) is a ubiquitous cellular process that occurs in all three domains of life as well as in DNA and RNA viruses. In eukaryotes, HR is critically important for homology-directed DNA repair (HDDR) ...
Astrocytes regulate oligodendrocyte development and myelination in the mammalian brain
Oligodendrocytes (OLs), a type of glial cell, are the main myelinating cells of the mammalian central nervous system (CNS), enabling efficient saltatory mode of nerve conduction. On the other hand, astrocytes, another glial ...
Algorithms for Investigating, Decoding and Designing ligand recognition sites in proteins - A Structural Bioinformatics Approach to Studying Protein Function
All physical processes in living organisms are driven by specific biomolecular interactions.
Elucidating the characteristics of biomolecular interactions between proteins and their respective
small molecule ligands can ...
On mechanisms and conformational dynamics of Drug:H+ Antiporters
Multidrug efflux is an active transport process involving energy consumption to drive antibacterial compounds out of cells. This is performed either through primary active transport, where chemical energy, such as hydrolysis ...
Understanding the role of DNAJC30 and ISCU in mitochondrial homeostasis
Williams-Beuren Syndrome (WBS) is a rare multisystem genomic disorder characterized by mild to moderate cognitive impairment, unique personality traits, distinctive facial features, cardiovascular problems, and infantile ...
Characterization of Visual Stimulus-Induced Gamma Oscillations as Signatures of Mechanisms Underlying Healthy Aging and Disease
Neural oscillations are rhythmic fluctuations in the electrical activity recorded from the brain that convey important information about brain function. Gamma oscillations, which refer to the 30–80 Hz frequency range, are ...