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miRNA-based regulation of Coxsackievirus B3 replication and pathogenesis
Coxsackievirus B3 (CVB3) is a single-stranded, positive-sense RNA virus known to cause
acute myocarditis, pancreatitis, and aseptic meningitis. In many cases, the long-term impact of
CVB3 infection-induced cell death ...
Role of 3D-organization of the X-inactivation centre in imprinted X-chromosome inactivation
The connection between 3D-genome organization and genome regulation is one of the fundamental questions in modern biology. In a nucleus, the genome is organized through different layers of 3D-organization such as ...
Conformational Heterogeneity, Solution Structure and Autoregulatory Roles of the MazE9 Antitoxin from Mycobacterium tuberculosis
The work presented in this thesis endeavors to decode the details of the dynamics of MazE9 antitoxin of the Mycobacterium tuberculosis MazEF9 toxin-antitoxin system and the transcriptional autoregulation effected by it. ...
On mechanisms and conformational dynamics of Drug:H+ Antiporters
Multidrug efflux is an active transport process involving energy consumption to drive antibacterial compounds out of cells. This is performed either through primary active transport, where chemical energy, such as hydrolysis ...
Metabolic and Pharmacological Modulations During IFN-γ signaling
Interferons, initially discovered for their antiviral properties, play pivotal roles in various biological processes, including host defense against pathogens, tumor surveillance, and disease pathogenesis. Interferon-gamma ...
Elucidating the Role of miR-617 in Oral Squamous Cell Carcinoma Pathogenesis
Oral Squamous Cell Carcinoma (OSCC) or oral cancer is the malignancy of the epithelial lining
of the oral cavity. It is the leading cause of cancer-related mortality in Indian males and despite
technological advancements, ...
Role of Sirtuin 2 in the development of tissue fibrosis
Wound healing is a crucial physiological process required for the healthy lifespan of an
organism. Dysregulation in the process of wound healing leads to the production of excess
extracellular matrix leading to fibrosis. ...
Understanding the interaction mechanism of bacterial virulence factors and effector proteins with host lipid membrane using single particle cryo-electron microscopy
Pathogenic bacteria employ an array of biological macromolecules and cellular
structures that help in the initiation and progression of disease in host organism.
These ‘virulence factors’ can either be secreted by the ...
Venomics of Medically Important yet Neglected Elapid Snakes of India and the Antivenomic Potential of Plant Extracts
India is considered the world's snakebite capital, where over 58,000 snakebite fatalities are registered annually. Most bites are primarily attributed to four snake species: the spectacled cobra (Naja naja), common krait ...
Understanding protein structural excursions using residue networks and implications on biological function
The information required for a protein structure to fold into the native conformation is encoded in its sequence. Studying protein structures help to understand their biological function. Molecular interactions between ...