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Biochemical and functional characterisation of cyclic AMP-binding, universal stress proteins from mycobacteria
The genus Mycobacterium harbours several pathogenic species, including M. tuberculosis, the causative agent of tuberculosis, which alone is responsible for nearly 1.3 million deaths globally every year. Understanding the ...
Biochemical, Genetic and Molecular characterization of TCP3 and TCP4 transcription factors in Arabidopsis thaliana
The TEOSINTE BRANCHED1, CYCLOIDEA, PROLIFERATING CELL FACTORs (TCP) family of proteins consists of plant-specific, non-canonical basic helix-loop-helix transcription factors that perform diverse developmental processes. ...
Altering DNA topology in mycobacteria: impact of perturbation of DNA gyrase on physiology and gene expression
In the current dissertation, efforts have been made to probe the in vivo role of DNA gyrase to determine its importance in the growth, physiology and gene expression in mycobacteria. In this dissertation, the role of DNA ...
Role of conserved features of initiator tRNA and ribosome heterogeneity in translation initiation in Escherichia coli
Translation is one of the fundamental and core cellular processes catalysed by a ribonucleoprotein complex called ribosome. The process involves four major steps: initiation, elongation, termination and recycling. Initiation ...
Genetics of Glioblastoma: Insights into Biology and Therapy Resistance
The central nervous system contains the neural stem cells which differentiate and give rise to the neurons as well as the glial cells which are non-neuronal in nature and provide support and protection to neurons. Unlike ...
Regulation of Hepatitis C Virus life-cycle by lncRNA HULC: crosstalk with other host factors
Hepatitis C virus (HCV) is a positive sense single-stranded RNA virus. It belongs to the family Flaviviridae and the genus hepacivirus. Following the receptor-mediated endocytosis, HCV genome is released into the cytoplasm, ...
Local Interactions, Spatial Patterns and Ecosystem Stability
Many ecosystems exhibit striking patterns in the spatial distribution of organisms, for
example, patterns of clumping and dispersion in semi-arid vegetation, mussel in intertidal
beds and even sea-grass and macroalgae. ...
Influence of the substrate specificity of Mycobacterium tuberculosis ClpX on the transcriptional profile
Cellular homeostasis in bacteria is maintained by diverse molecular machines. These include several one-component systems (OCS), two- component systems (TCS), chaperone proteins, proteases, proteolytic complexes and ...
Understanding the regulation of translation and replication of Coxsackievirus B3 RNA by host RNA binding proteins
Coxsackievirus B3 (CVB3) is an enterovirus, with a positive-sense single-stranded RNA genome. The genome contains a single open reading frame (ORF) flanked by untranslated regions (UTR) at the 5’ and 3’ ends. The viral ...
Use of Human Induced Pluripotent Stem Cells as a Model to Study Primary Microcephaly
The aim of this study was to use human induced pluripotent stem cells (hiPSC) to understand key steps of neuronal differentiation and to model the human brain developmental disorder, primary microcephaly (MCPH). MCPH is a ...