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Structural and functional insights into hybrid AT-less megaenzyme synthase (NRPS) and DNA-MsDps2 complexes using single particle cryo-EM
Microorganisms, mainly bacteria and fungi, are the producers of structurally diverse, complex organic compounds called as secondary metabolites. These metabolites include polyketides (PKs), non-ribosomal peptides (NRPs), ...
Development of 3D model and understanding translational regulation of breast cancer
Breast cancer is the most common cancer among women in India and worldwide. It is a highly heterogeneous disease caused by several genetic and epigenetic alterations in mammary epithelial cells. Both inter- and intra-patient ...
Studies on the promoter specificity determinants and modulators of the prokaryotic transcription machinery
Bacteria adapt to a wide range of environmental conditions by synchronizing transcription with changes in the extracellular environment. This is achieved by the synchronized action of two-component systems, Extra Cytoplasmic ...
Post translational modification and DNA binding studies with two nucleoid associated proteins of Mycobacterium tuberculosis
Genome in prokaryotes is found in a small confinement called nucleoid. The nucleoid compaction is brought about by the combined action of topoisomerases and Nucleoid associated proteins (NAPs). Topoisomerases maintain ...
Biochemical and structural studies to provide insights into initiator tRNA delivery by eIF2A in noncanonical translation initiation
Eukaryotic initiation factor 2A (eIF2A), a non-canonical translation initiation factor, delivers initiator tRNA (tRNAi) onto the 40S ribosomal subunit in a codon-dependent and GTP-independent manner, unlike the canonical ...
Epigenetic modulation of Foam cell generation during Mycobacterium tuberculosis/ Cryptococcus neoformans infection
Foamy macrophages or Foam cells are a critical cellular component of the granuloma formed during pulmonary infection. These lipid rich cells generally contain neutral lipids, Cholesteryl Esters (CE) and/or Triglycerides ...
Structural and functional insights into hybrid AT-less megaenzyme synthase (NRPS) and DNA-MsDps2 complexes using single particle cryo-EM
Microorganisms, mainly bacteria and fungi, are the producers of structurally diverse, complex organic compounds called as secondary metabolites. These metabolites include polyketides (PKs), non-ribosomal peptides (NRPs), ...
Characterization of Neuroprotective Reactive Astrocytes in the Aging Mammalian Brain
The brain manifests cognitive deficits in aging and becomes more vulnerable to neurodegeneration. Astrocytes play several critical roles in the brain, including synapse formation, maturation, elimination, and synaptic ...
Understanding cholesterol homeostasis and its impact on GPCR signalling in aging
Full text embargo One year up to July 2024
Aging is defined as the time-related deterioration of physiological functions necessary for survival of organisms. Despite significant progress in the extension of human lifespan ...
Molecular pathways governing maturation and decay of precursor piRNAs in Caenorhabditis elegans
Piwi-interacting RNAs (piRNAs) are an animal-specific class of germline-enriched small non-coding RNAs that play a crucial role in germline development and fertility in diverse organisms. In Caenorhabditis elegans (C. ...