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Now showing items 11-20 of 122
Understanding the role of arginine clusters in β-hairpin antimicrobial peptides
The work described in this thesis describes the role of arginine clusters and the
importance of their position in B-hairpin antimicrobial peptides. Here, we have
tried to explore the role of guanidinium groups in the ...
Role of Escherichia coli UvrD helicase in resolving G-quadruplex DNA structures
G-quadruplex (G4) secondary structures have been implicated in various biological processes,
including gene expression, DNA replication and telomere maintenance. However,
unresolved G4 structures impede replication ...
Ageing associated altered host response to bacterial infection
Chapters in which I have elucidated and elaborately described how senescence alters the cellular response to infection, here I demonstrate how senescence in multiple tissues simultaneously contribute to pathogen spread and ...
Structural and functional studies on a small Heat Shock Protein from Entamoeba histolytica
Small Heat Shock Proteins (sHSPs) are molecular chaperones that bind to unfolding proteins during cellular stress to prevent them from aggregation. Once the normal conditions are restored, sHSPs release the bound substrate ...
Functional Characterization of a SAND–Domain–containing Factor OsULTRAPETALA1 – a Direct Downstream Target of OsMADS1
Studies on meristem identity regulators in Rice (Oryza sativa), a model plant for cereal crops have revealed how meristem identity and transitions are controlled, bearing implications for crop yield improvement. We were ...
Studies on differentiation of mouse GS-2 ES-cells to pancreatic β-islet-like cells and their functional maturation status
Embryonic stem cells (ES-cells) are an excellent source for generating insulin-producing β-islet cells for potential use in the management of diabetes mellitus. Although many protocols have been developed to promote the ...
Roles of N10-formyl-tetrahydrofolate (N10-fTHF), ribosomal large subunit pseudouridine synthase D (RluD), and transcription-translation coupling in the fidelity of translation initiation in Escherichia coli
Protein synthesis is a fundamental process in gene expression. It involves four basic steps – initiation, elongation, termination, and ribosome recycling in bacteria. However, the step of initiation is the most regulated ...
Studies on Nudix hydrolase proteins and crosstalk between DNA repair pathways
Mycobacterium tuberculosis, the causative agent of tuberculosis, has become a global health concern. This calls for a dire need to understand various aspects of mycobacterial physiology in order to design better strategies ...
Regulation of auxin response by UBIQUITIN-SPECIFIC PROTEASE14/ TARANI in Arabidopsis thaliana
The genetic pathway regulating auxin response in Arabidopsis is well established and provides us a framework to assess whether TNI belongs to this pathway. The total number of lateral roots is taken as a read-out of auxin ...
Understanding the Role of SIRT2 in Cardiac Hypertrophy, Cell Death and Glucose Homeostasis
Over the last century the major causes of human deaths and ailments has shifted from acute infectious diseases to chronic aging related disorders like cancer and type-2 diabetes. The aging process is a universal property ...