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Immunological consequences of host signaling-regulated epigenetic modification(s) during mycobacterial pathogenesis
Introduction: Mycobacterium tuberculosis (Mtb), the principal etiological agent of pulmonary tuberculosis (TB), continues to co-evolve with the human population making itself one of the most potent infectious killer in the ...
Characterization of the transsulfuration enzyme Cystathionine beta-synthase as a novel regulatory node in the sulfur metabolism of Mycobacterium tuberculosis
Methionine and cysteine metabolisms are important for the survival and pathogenesis of Mycobacterium tuberculosis (Mtb). The transsulfuration pathway converts methionine to cysteine and represents an important link between ...
Ageing associated altered host response to bacterial infection
Chapters in which I have elucidated and elaborately described how senescence alters the cellular response to infection, here I demonstrate how senescence in multiple tissues simultaneously contribute to pathogen spread and ...
Studies on Nudix hydrolase proteins and crosstalk between DNA repair pathways
Mycobacterium tuberculosis, the causative agent of tuberculosis, has become a global health concern. This calls for a dire need to understand various aspects of mycobacterial physiology in order to design better strategies ...
Biochemical and functional characterisation of cyclic AMP-binding, universal stress proteins from mycobacteria
The genus Mycobacterium harbours several pathogenic species, including M. tuberculosis, the causative agent of tuberculosis, which alone is responsible for nearly 1.3 million deaths globally every year. Understanding the ...
Manipulating Bacterial and Host Reactive Oxygen Species (ROS)- based mechanisms to potentiate killing of Mycobacterium tuberculosis (Mtb)
Mycobacterium tuberculosis (Mtb) is evolutionarily equipped to resist exogenous reactive oxygen species but shows vulnerability to an increase in endogenous ROS (eROS). Since eROS is an unavoidable consequence of aerobic ...
Malat1 and COP1 mediated host responses orchestrate mycobacterial pathogenesis
Tuberculosis, which is caused by Mycobacterium tuberculosis (Mtb), is viewed to be the predominant cause of death arising due to bacterial infection. Further, the emergence of MDR/XDR strains and co-infections has compounded ...
Biochemical and Functional Characterization of the Mycobacterial PdtaS-PdtaR Two Component System
Two-Component Systems (TCSs) are primarily prokaryotic modes of cell signaling involving a receptor sensor kinase (SK) that senses stimuli and a response regulator (RR) that effects a response, usually at the level of ...
Post translational modification and DNA binding studies with two nucleoid associated proteins of Mycobacterium tuberculosis
Genome in prokaryotes is found in a small confinement called nucleoid. The nucleoid compaction is brought about by the combined action of topoisomerases and Nucleoid associated proteins (NAPs). Topoisomerases maintain ...
Epigenetic modulation of Foam cell generation during Mycobacterium tuberculosis/ Cryptococcus neoformans infection
Foamy macrophages or Foam cells are a critical cellular component of the granuloma formed during pulmonary infection. These lipid rich cells generally contain neutral lipids, Cholesteryl Esters (CE) and/or Triglycerides ...