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Role of TCP4 Transcription Factor in the Maturation Program of Arabidopsis Life Cycle
(2018-07-28)
TCP4 as an integrator of key developmental events
A striking aspect of plant life is their sedentary life-style. Though it relieves them of the obligation of forming a complex body organization, it exposes them to ...
Unravelling the Mechanism of Bactericidal/Permeability-Increasing Protein Expression during Bacterial Pathogenesis
(2018-02-21)
Anti-microbial proteins (AMP) are the key effector arm of the innate immune system. The prevalence of AMP in single-celled eukaryotes to humans shows its importance during the course of evolution. The first report for the ...
Studies on Interactions between ARE Binding Proteins and Splicing Factors and their Role in Altered Splicing of PDGF-B ORF
(2018-03-03)
Pre-mRNA splicing is an important level in posttranscriptional gene regulation that is essential for accurate protein synthesis and generating protein diversity. The abundance of cryptic splice sites and long intronic DNA ...
Mechanistic Insights into Translation and Replication of Hepatitis C Virus RNA : Exploring Direct-Acting Antivirals
(2018-03-09)
Hepatitis C virus (HCV), a blood-borne pathogen, is a small enveloped RNA virus belonging to the Hepacivirus genus of the Flaviviridae family. HCV infection represents one of the major health concerns affecting approximately ...
Map-based Cloning and Characterization of TARANI, a Global Regulator of Arabidopsis Development
(2018-03-02)
Forward genetic screen was performed in Arabidopsis thaliana to isolate novel genes involved in leaf development. The tarani (tni) mutant was selected for further study based on its unique cup-shaped lamina with +ve Gaussian ...
Racemases in Salmonella : Insights into the Dexterity of the Pathogen
(2018-02-27)
Chapter -I
Introduction
Salmonella is a pathogen well-known for its ability to infect a wide variety of hosts and causes disease ranging from mild gastroenteritis to typhoid fever. During infection, it is exposed to a ...
Characterization of the Cis and Trans Acting Factors that Influence p53 IRES Function
(2018-03-07)
p53 is a nodal tumor suppressor protein that acts as a major defense against cancers. Approximately 50% of human tumours have mutations in p53 gene. Among its myriad features, the most distinctive is the ability to elicit ...
Characterization of an In Vitro Transcription System for Peste Des Petits Ruminants Virus and Functional Characterization of RNA Triphosphatase Activity of RNA Dependent RNA Polymerase Protein L
(2018-03-03)
Peste des petits ruminants virus (PPRV) belongs to the family paramyxoviridae which comprises non segmented negative sense RNA viruses including measles and rinderpest virus. PPRV is the causative agent of peste des petits ...
Studies on Regulation of Rat Corpus Luteum Function by Prolactin And Luteinizing Hormone
(2018-07-25)
The corpus luteum (CL) is a transient endocrine structure formed from the remnants of an ovulated follicle with the primary purpose of producing progesterone (P4), a hormone vital for the establishment and maintenance of ...
Role of AMP-Activated Protein Kinase in Cancer Cell Survival under Matrix-Deprived Conditions
(2018-07-19)
Cancer progression is a multi-step process requiring cells to acquire specific properties that aid the neoplastic growth. One such property is the ability to survive in the absence of matrix-attachment, a critical necessity ...